Head-to-head · Cost-Efficiency Index
PCOS Sisters vs Vyora Wellness
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
PCOS Sisters
Cost-first shoppers who want women with PCOS who want GLP-1 prescribing folded into a specialty metabolic-care membership.
Visit PCOS SistersVyora Wellness
Shoppers who want one flat price that never changes as their GLP-1 dose is titrated up.
Visit Vyora WellnessThe verdict
PCOS Sisters and Vyora Wellness tie on the Cost-Efficiency Index at 52/100, so neither wins outright on the numbers. For most shoppers we'd start with PCOS Sisters (ranked #390, a hair above #393) — Cost-first shoppers who want women with PCOS who want GLP-1 prescribing folded into a specialty metabolic-care membership. But Vyora Wellness is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs PCOS Sisters.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | PCOS Sisters | Vyora Wellness |
|---|---|---|
| Cost-Efficiency Index | 52/100 | 52/100 |
| Semaglutide / mo | Not disclosed | $299/mo (all doses, compounded) |
| Tirzepatide / mo | Not disclosed | $399/mo |
| Semaglutide / yr (modeled) | — | $3,588 |
| Tirzepatide / yr (modeled) | — | $4,788 |
| Coverage | 12 states | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #390 | #393 |
PCOS Sisters
52/100Where the value is
- Dedicated PCOS specialty model with a metabolic weight-loss program and fitness app bundled into the membership
- Two named pharmacy partners with full addresses published (Strive Pharmacy, Gilbert AZ; Striker Pharmacy, Katy TX)
- LegitScript and BBB verification badges both present on-site
The tradeoffs
- The advertised $150/month does NOT include the GLP-1 medication itself — the site's own FAQ confirms medication is billed separately by the pharmacy, so the real all-in cost is higher and undisclosed
- Only 11 states served (not 12), with no public timeline for expansion beyond 'working to expand our coverage'
Vyora Wellness
52/100Where the value is
- Genuinely flat-rate pricing confirmed by its own FAQ — the monthly cost does not rise as the dose increases, unlike per-dose-tier competitors
- LegitScript certification verified to actually render on the live homepage (real badge and outbound verification link, not commented-out code)
- Coaching, nutritional guidance, and community access are bundled into the price at no extra charge
The tradeoffs
- Above-average flat pricing ($299-$399/mo) compared to per-dose-tier or 12-month-prepay competitors that can undercut it at low starting doses
- No specific compounding pharmacy is named — only a generic '503A certified pharmacies' claim
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.