Head-to-head · Cost-Efficiency Index
Optimized Health vs PeptidesRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Optimized Health
Shoppers who want a simple, all-inclusive starting price with no separate visit or membership fee, in one of five served states.
Visit Optimized HealthPeptidesRx
Cost-first shoppers who want itemized per-vial pricing across every dose tier, for shoppers who read past the '1-week starter' teaser price.
Visit PeptidesRxThe verdict
Optimized Health and PeptidesRx tie on the Cost-Efficiency Index at 55/100, so neither wins outright on the numbers. For most shoppers we'd start with Optimized Health (ranked #342, a hair above #343) — Shoppers who want a simple, all-inclusive starting price with no separate visit or membership fee, in one of five served states. But PeptidesRx is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Optimized Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Optimized Health | PeptidesRx |
|---|---|---|
| Cost-Efficiency Index | 55/100 | 55/100 |
| Semaglutide / mo | $200/mo (starting dose, plus a separate fee, compounded) | $321/mo (10 mg dose, compounded) |
| Tirzepatide / mo | $250/mo (starting dose, bundle, compounded) | $576/mo (40 mg dose, compounded) |
| Semaglutide / yr (modeled) | $2,400 | $3,852 |
| Tirzepatide / yr (modeled) | $3,000 | $6,912 |
| Coverage | 5 states | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #342 | #343 |
Optimized Health
55/100Where the value is
- Genuinely bundled pricing: the advertised $200/$250 figures are stated to include medication, monitoring, and provider care with 'no contracts'
- LegitScript certified, with the verification link published on-site
- HSA/FSA accepted
The tradeoffs
- Single-provider practice: Mathew Hammons, PA-C is named on-site as 'The Only Licensed Prescriber,' with no backup clinician or named medical director disclosed
- Telehealth is limited to just five states (Missouri, Iowa, Kansas, Utah, Washington) plus one in-person Joplin, MO clinic
PeptidesRx
55/100Where the value is
- Confirmed legitimate clinical telehealth service — licensed provider consultation required before any prescription, with no 'research use only' disclaimer anywhere
- Every dose tier for both drugs is individually priced and published, more granular transparency than most competitors in this batch
- Cancel-anytime, no long-term contract on any SKU
The tradeoffs
- The homepage's 'From $185/mo' and 'From $304/mo' teaser prices are for vials the catalog itself labels a '1-week starter' supply — the genuine 4-week tier costs 69-89% more, and this gap is easy to miss since every tier bills as a monthly auto-renewal regardless of the vial's actual duration
- No compounding pharmacy is individually named, only 'PCAB-accredited US pharmacies'
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.