Head-to-head · Cost-Efficiency Index
Onyx Weight Loss vs Try Ageless
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Onyx Weight Loss
Patients located in one of Onyx's 8 served states who want a boutique, NP-led clinic bundling weight loss with hormone and peptide care.
Visit Onyx Weight LossTry Ageless
Shoppers who weight a named, checkable pharmacy and a verifiable prescriber above a low sticker, and who will read past the entry-price cards to the month-to-month column beneath them.
Visit Try AgelessThe verdict
Onyx Weight Loss takes it, leading the Cost-Efficiency Index 51 to 48. Onyx Weight Loss is a small, nurse-practitioner-founded telehealth clinic (no MD medical director identified) serving 8 named states, offering GLP-1 and GLP-1/GIP medications alongside HRT and peptide therapy. Try Ageless still earns a C — Shoppers who weight a named, checkable pharmacy and a verifiable prescriber above a low sticker, and who will read past the entry-price cards to the month-to-month column beneath them.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Onyx Weight Loss.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Onyx Weight Loss | Try Ageless |
|---|---|---|
| Cost-Efficiency Index | 51/100 | 48/100 |
| Semaglutide / mo | Not disclosed | $279/mo injection with B12 (compounded) |
| Tirzepatide / mo | Not disclosed | $199/mo sublingual drops, $349/mo injection (compounded) |
| Semaglutide / yr (modeled) | — | $3,348 |
| Tirzepatide / yr (modeled) | — | $2,388 |
| Coverage | 8 states | Not published |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #402 | #406 |
Onyx Weight Loss
51/100Where the value is
- Clear, specific 8-state service list published
- Bundles weight loss with hormone replacement and peptide therapy under one clinic
- Small team with named founders and identifiable clinical staff
The tradeoffs
- No pricing published anywhere on the public site
- No physician/MD medical director -- leadership is NP/RN-only
Try Ageless
48/100Where the value is
- The compounding pharmacy is NAMED and lookupable — The Pharmacy Hub, Miami FL — which most of this ranking's programs never manage
- The prescriber is named AND independently verifiable: Wasef Health, PC, medical prescriber Michael Wasef, MD, NPI 1417261926, which resolves in NPPES to an active Internal Medicine registration with a Florida license
- Three routes on one plan — semaglutide injection, tirzepatide injection and sublingual tirzepatide drops — and the clinician may switch your format under the existing plan at no extra fee
The tradeoffs
- The two "ENTRY PRICE" cards and the hero all advertise yearly prepay rungs as monthly rates — "from $199/mo" semaglutide, "from $249/mo" tirzepatide and "$159/mo from" on the drops are the 12-month rungs, requiring $2,388, $2,988 and $1,908 up front; the true month-to-month prices are $279, $349 and $199
- Its own two commerce paths disagree by more than half: the public tryageless.com shop lists the same semaglutide injection at $119 to $229 depending on prescribed dose, as a one-time purchase "for a month supply", while the plan page our link leads to starts at $279 month-to-month
Regulatory note: the FDA issued a warning letter to Lovely Meds, Inc. dba Lovely Meds in September 2025. We still list and link to Try Ageless; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.