Head-to-head · Cost-Efficiency Index
CoreAge Rx vs Onyx Weight Loss
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
CoreAge Rx
Anyone optimizing for real value — a transparent flat price you can model for a full year, nationwide, without a bait-and-switch.
Visit CoreAge RxOnyx Weight Loss
Cost-first shoppers who want nP-led GLP-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl.
Visit Onyx Weight LossThe verdict
CoreAge Rx takes it, leading the Cost-Efficiency Index 94 to 59. Best value on the board: both molecules at one flat, all-50 price with no teaser step-ups — the lowest true cost of ownership, not the lowest teaser. Onyx Weight Loss still earns a C — Cost-first shoppers who want nP-led GLP-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | CoreAge Rx | Onyx Weight Loss |
|---|---|---|
| Cost-Efficiency Index | 94/100 | 59/100 |
| Semaglutide / mo | $149/mo | $228/mo (starting dose, compounded) |
| Tirzepatide / mo | $349/mo | $280/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $1,788 | $2,736 |
| Tirzepatide / yr (modeled) | $4,188 | $3,360 |
| Coverage | All 50 states | 8 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank on the board | #1 | #258 |
CoreAge Rx
94/100Where the value is
- Flat all-in monthly price — no intro rate that silently triples after month one, so the modeled annual cost is the real cost
- Both compounded semaglutide and tirzepatide on one account at published prices
- Available in all 50 states — no coverage gamble
The tradeoffs
- Not the rock-bottom sticker price — cheaper teaser tiers exist (Direct GLP lists $65, Ondra $93 on semaglutide)
- No FDA-approved brand-name option (compounded only)
Onyx Weight Loss
59/100Where the value is
- Competitive entry pricing: semaglutide from $228/mo and tirzepatide from $280/mo with medication + supplies included
- Nurse-practitioner-led care: founder Tasha Vangile FNP-C (20+ years) and Stephanie Robison APRN-CNP (27 years experience)
- Low-cost $99/mo GLP-1 microdosing option for patients who prefer a gradual titration start
The tradeoffs
- Only 8 states (NC, CO, ME, VT, VA, IA, NH, PA) — excludes the majority of the US
- No LegitScript certification; credentialing evidence limited to local 2025 Best of Iredell award
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.