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WeighLab

OnlyRx vs Knownwell

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

OnlyRx

Provider comparison

Shoppers who want a 50-state marketplace with multiple pharmacy options and named prescribers.

Semaglutide / month
$179/moStarting dose, compounded
Tirzepatide / month
$249/moStarting dose, compounded
Index 77/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check OnlyRx pricing Read review

Knownwell

Provider comparison

Insured shoppers who want an obesity-medicine specialist overseeing brand-name GLP-1 care, with published self-pay drug prices as a fallback.

Semaglutide / month
$149/moBrand Wegovy pill, 1.5 mg starting dose, visits billed separately; Wegovy pen $349/mo, new patients $199/mo for the first 2 months
Tirzepatide / month
$299/moBrand Zepbound vial or KwikPen, 2.5 mg starting dose, visits billed separately
Index 77/100 · Grade CChecked October 2026
Check Knownwell pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Both score 77/100 on the Cost-Efficiency Index. There is no score winner; compare the treatment you need, billing terms and state availability.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

OnlyRx

Knownwell

Semaglutide / month
OnlyRx: $179/moStarting dose, compounded
Knownwell: $149/moBrand Wegovy pill, 1.5 mg starting dose, visits billed separately; Wegovy pen $349/mo, new patients $199/mo for the first 2 months
Tirzepatide / month
OnlyRx: $249/moStarting dose, compounded
Knownwell: $299/moBrand Zepbound vial or KwikPen, 2.5 mg starting dose, visits billed separately
Semaglutide / year (modeled)
OnlyRx: $2,148
Knownwell: $1,788
Tirzepatide / year (modeled)
OnlyRx: $2,988
Knownwell: $3,588
State availability
OnlyRx: All 50 states
Knownwell: All 50 states
Oral / sublingual option listed
OnlyRx: Yes
Knownwell: Yes
Brand-name access listed
OnlyRx: Yes
Knownwell: Yes
Provider facts checked
OnlyRx: October 2026
Knownwell: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

OnlyRx

Shoppers who want a 50-state marketplace with multiple pharmacy options and named prescribers.

Reasons to consider it

  • Says it serves all 50 states
  • Names physicians at Lion MD with public NPI numbers
  • Lists four pharmacy partners with contact information

What to weigh up

  • The banner still calls $179 a Summer Promo, while product cards say starting at; confirm the ongoing rate
  • No dose-by-dose price list is published
  • Ask which of the four pharmacy partners will fill your prescription

Compounded drugs are not FDA-approved. Understand the medication options.

Check OnlyRx pricing Read the full OnlyRx review

Knownwell

Insured shoppers who want an obesity-medicine specialist overseeing brand-name GLP-1 care, with published self-pay drug prices as a fallback.

Reasons to consider it

  • Co-founded and clinically led by Dr. Angela Fitch, a named, credentialed obesity-medicine specialist (Chief Medical Officer)
  • Prescribes branded FDA-approved GLP-1s across the current class (Wegovy, Zepbound, Ozempic, Saxenda) plus orforglipron/Foundayo
  • Publishes a self-pay price for every drug and dose, from $149 a month for the Wegovy pill

What to weigh up

  • Brand-name only, and the price rises with the dose: the Wegovy pill runs $149 to $299 a month, the Wegovy pen $349, and Zepbound $299 to $449
  • Those are medication prices; without insurance, knownwell's own visits cost $299 for the first and $149 for each follow-up
  • In-person care is limited to five states (Texas has primary care in Plano only), so most of the country can only use the virtual clinic
Check Knownwell pricing Read the full Knownwell review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

OnlyRxKnownwell
Normalized Cost/Month
OnlyRx:
68/100
Knownwell:
73/100
Price Transparency
OnlyRx:
84/100
Knownwell:
72/100
Nationwide Access
OnlyRx:
86/100
Knownwell:
86/100
Formulation Options
OnlyRx:
90/100
Knownwell:
95/100
Clinical Oversight
OnlyRx:
72/100
Knownwell:
82/100
Contract Flexibility
OnlyRx:
55/100
Knownwell:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.