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WeighLab

One80Rx vs Rex MD

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

One80Rx

Provider comparison

Shoppers who want an injectable or oral GLP-1 with peptide therapies on the same account and will confirm their exact price after the provider review.

Semaglutide / month
$129/moStarting price, compounded; confirmed after provider review
Tirzepatide / month
$229/moStarting price, compounded; confirmed after provider review
Index 72/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check One80Rx pricing Read review

Rex MD

Provider comparison

Patients seeking a Wegovy pill plan with medication and provider care in one monthly price.

Semaglutide / month
$349/moBrand Wegovy pill, all titration doses; provider care included
Tirzepatide / month
$424/moBrand Zepbound, plus a separate fee
Index 71/100 · Grade CChecked October 2026
Check Rex MD pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

One80Rx has the higher Cost-Efficiency Index: 72/100 versus 71/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

One80Rx
Not published
Rex MD
All 50 states

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

One80Rx

Rex MD

Semaglutide / month
One80Rx: $129/moStarting price, compounded; confirmed after provider review
Rex MD: $349/moBrand Wegovy pill, all titration doses; provider care included
Tirzepatide / month
One80Rx: $229/moStarting price, compounded; confirmed after provider review
Rex MD: $424/moBrand Zepbound, plus a separate fee
Semaglutide / year (modeled)
One80Rx: $1,548
Rex MD: $4,188
Tirzepatide / year (modeled)
One80Rx: $2,748
Rex MD: $5,088
State availability
One80Rx: Not published
Rex MD: All 50 states
Oral / sublingual option listed
One80Rx: Yes
Rex MD: Yes
Brand-name access listed
One80Rx: Not confirmed
Rex MD: Yes
Provider facts checked
One80Rx: October 2026
Rex MD: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

One80Rx

Shoppers who want an injectable or oral GLP-1 with peptide therapies on the same account and will confirm their exact price after the provider review.

Reasons to consider it

  • Starting prices for every program are listed on its treatments page: semaglutide $129, a GLP-1 microdose $149, an oral GLP-1 $149 and tirzepatide $229 a month
  • Promises flat-rate pricing with no consultation charge and no surcharge when your dose changes
  • You pay $0 if you aren't approved, and shipping is free in two to three days

What to weigh up

  • Every price is a "from" figure, and the site says plans are confirmed after provider review, so the price for your dose isn't published
  • The semaglutide and tirzepatide program pages show no price at all; the figures appear only on the homepage banner and the treatments list
  • It doesn't name its compounding pharmacies or its medical group, and says only that it serves the states where it is licensed

Compounded drugs are not FDA-approved. Understand the medication options.

Check One80Rx pricing Read the full One80Rx review

Rex MD

Patients seeking a Wegovy pill plan with medication and provider care in one monthly price.

Reasons to consider it

  • Wegovy pill plan includes medication and provider care for $349 monthly
  • The pill price is locked across listed titration doses
  • Names Dr. Anthony Puopolo and the Rex MD Affiliated Medical Group

What to weigh up

  • The $349 pill plan differs from the injection route with separate program and manufacturer charges
  • Zepbound pricing depends on the prescribed dose and manufacturer terms
  • The weight program does not accept insurance
Check Rex MD pricing Read the full Rex MD review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

One80RxRex MD
Normalized Cost/Month
One80Rx:
92/100
Rex MD:
41/100
Price Transparency
One80Rx:
94/100
Rex MD:
78/100
Nationwide Access
One80Rx:
24/100
Rex MD:
86/100
Formulation Options
One80Rx:
77/100
Rex MD:
90/100
Clinical Oversight
One80Rx:
73/100
Rex MD:
89/100
Contract Flexibility
One80Rx:
61/100
Rex MD:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.