Head-to-head · Cost-Efficiency Index
Omzo vs 1st Optimal
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Omzo
Cost-first shoppers who want not clearly assessable without pricing transparency; unsuitable to recommend confidently in a price comparison.
Visit Omzo1st Optimal
Patients who want a named founding physician and a broader functional-medicine/hormone workup alongside GLP-1s.
Visit 1st OptimalThe verdict
Omzo takes it, leading the Cost-Efficiency Index 42 to 41. Omzo is a multi-condition telehealth brand offering semaglutide, tirzepatide, and branded Ozempic access alongside women's hormone, sexual health, and skin/hair services. 1st Optimal still earns a C — Patients who want a named founding physician and a broader functional-medicine/hormone workup alongside GLP-1s.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Omzo.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Omzo | 1st Optimal |
|---|---|---|
| Cost-Efficiency Index | 42/100 | 41/100 |
| Semaglutide / mo | Not disclosed | Not disclosed |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | — | — |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | Yes |
| Brand-name access | Yes | Compounded only |
| Rank here | #514 | #518 |
Omzo
42/100Where the value is
- Broad multi-condition offering beyond weight loss (hormones, sexual health, skin, hair)
- States semaglutide and tirzepatide are both available
- Emphasizes licensed clinician review of every plan
The tradeoffs
- No pricing disclosed anywhere without completing a personal-data intake quiz
- No medical director named
1st Optimal
41/100Where the value is
- Named founder and clinical lead: Dr. Amber Miller, a functional medicine physician
- LegitScript verification badge displayed
- No credit card required to start the intake quiz
The tradeoffs
- No GLP-1 pricing published anywhere on the public site
- No compounding pharmacy partner named
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.