Head-to-head · Cost-Efficiency Index
NewSelf vs RxSpan MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
NewSelf
Budget shoppers who want a verified all-50 program and one of the lowest disclosed tirzepatide prices in the value tier.
Visit NewSelfRxSpan MD
Someone who wants to compare a compounded route against brand-name Zepbound or Wegovy without leaving one provider, and who will read past the twelve-month figure.
Visit RxSpan MDThe verdict
NewSelf takes it, leading the Cost-Efficiency Index 87 to 83. $100 semaglutide and $144 tirzepatide, nationwide and LegitScript-verified — near-identical value to the cheapest verified names, with the tirzepatide price a hair lower than most. RxSpan MD still earns a B — Someone who wants to compare a compounded route against brand-name Zepbound or Wegovy without leaving one provider, and who will read past the twelve-month figure.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs NewSelf.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | NewSelf | RxSpan MD |
|---|---|---|
| Cost-Efficiency Index | 87/100 | 83/100 |
| Semaglutide / mo | $100/mo | $249/mo month-to-month for the injection; $219 on three months, $199 on six and $194 on twelve |
| Tirzepatide / mo | $144/mo | $329/mo month-to-month for the injection; $309 on three months, $289 on six and $269 on twelve |
| Semaglutide / yr (modeled) | $1,200 | $2,988 |
| Tirzepatide / yr (modeled) | $1,728 | $3,948 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #12 | #17 |
NewSelf
87/100Where the value is
- $100 semaglutide / $144 tirzepatide — one of the cheapest verified combined prices in the ranking
- Nationwide all-50 coverage with both molecules published up front
- LegitScript-certified pharmacy behind the low price
The tradeoffs
- Compounded only — no brand-name or oral option
- Newer consumer brand with a thin public track record
Regulatory note: the FDA issued a warning letter to NewSelf Limited dba NewSelf in February 2026. We still list and link to NewSelf; you should know the letter is on the public record before you decide.
RxSpan MD
83/100Where the value is
- Every product and every term carries a published price, including the brand-name lane: Zepbound and Mounjaro at $1,069, Ozempic at $1,299 and Wegovy at $1,349
- Five routes on one account — injection, oral capsule, orally dissolving tablet, microdose injection and brand — which is the broadest formulary of anything ranked here
- A physician-founded program serving all 50 states
The tradeoffs
- The storefront renders no price at all without JavaScript: the catalog is reachable, but a reader with a blocked script sees nothing
- The figure a reader is most likely to meet elsewhere, around $194, is the twelve-month per-month rate; one month of the semaglutide injection is $249
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.