Head-to-head · Cost-Efficiency Index
Midi Health vs RxION Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Midi Health
Cost-first shoppers who want women already managing menopause who want their GLP-1 prescriber on the same platform, with no separate membership fee.
Visit Midi HealthRxION Health
Cost-first shoppers who want a flat, dose-independent monthly price with no titration surcharges, outside NJ/AK/MS.
Visit RxION HealthThe verdict
Midi Health and RxION Health tie on the Cost-Efficiency Index at 57/100, so neither wins outright on the numbers. For most shoppers we'd start with Midi Health (ranked #308, a hair above #311) — Cost-first shoppers who want women already managing menopause who want their GLP-1 prescriber on the same platform, with no separate membership fee. But RxION Health is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Midi Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Midi Health | RxION Health |
|---|---|---|
| Cost-Efficiency Index | 57/100 | 57/100 |
| Semaglutide / mo | $166/mo (0.5 mg dose, plus a separate fee, compounded) | $99/mo (all doses, plus a separate fee, compounded) |
| Tirzepatide / mo | $210/mo (2.5 mg dose, plus a separate fee, compounded) | $183/mo (all doses, compounded) |
| Semaglutide / yr (modeled) | $1,992 | $1,188 |
| Tirzepatide / yr (modeled) | $2,520 | $2,196 |
| Coverage | All 50 states | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #308 | #311 |
Midi Health
57/100Where the value is
- No membership fee — the site states outright 'You only pay for your care and your medications'
- Medication price already includes shipping and supplies, so the listed number is closer to the true out-of-pocket cost than sites that add fees later
- Dose-tiered pricing is published transparently: compounded semaglutide $165.90-$355.00/mo, compounded tirzepatide $210.00-$434.00/mo depending on dose
The tradeoffs
- The advertised 'Weekly doses start at $34' teaser on the weight-management overview page refers to microdosing, not the standard program — the real 4-week program cost starts at $165.90/mo, over 4x the teaser figure
- Weight care is not Midi's core identity — it's layered onto a menopause/HRT platform, so patients whose only need is GLP-1 may find a weight-loss-only provider more streamlined
RxION Health
57/100Where the value is
- One flat monthly price regardless of dose — no per-mg price ladder to climb as you titrate up
- Free cold-pack overnight shipping and injection supplies stated as included on both drug pages
- LegitScript Certified badge displayed and independently verifiable
The tradeoffs
- The displayed $99/$183 prices sit against a struck-through $199/$299 'regular' price with no stated end date — it is unclear whether this is a permanent or temporary rate
- Not available to residents of New Jersey, Alaska, or Mississippi
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.