Head-to-head · Cost-Efficiency Index
Medsol RX vs PlushCare
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Medsol RX
Shoppers who will actually commit to a 12-month prepay and want the lowest possible locked-in monthly rate.
Visit Medsol RXPlushCare
Patients who want a real board-certified physician managing GLP-1s alongside general primary care, and are prepared to navigate insurance or a manufacturer cash-pay program rather than a single flat price.
Visit PlushCareThe verdict
Medsol RX and PlushCare tie on the Cost-Efficiency Index at 65/100, so neither wins outright on the numbers. For most shoppers we'd start with Medsol RX (ranked #165, a hair above #166) — Shoppers who will actually commit to a 12-month prepay and want the lowest possible locked-in monthly rate. But PlushCare is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Medsol RX.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Medsol RX | PlushCare |
|---|---|---|
| Cost-Efficiency Index | 65/100 | 65/100 |
| Semaglutide / mo | $199/mo (compounded) | $199/mo (0.25 mg dose, plus a separate fee, brand-name) |
| Tirzepatide / mo | $259/mo (compounded) | $399/mo (5 mg dose, plus a separate fee, compounded) |
| Semaglutide / yr (modeled) | $2,388 | $2,388 |
| Tirzepatide / yr (modeled) | $3,108 | $4,788 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #165 | #166 |
Medsol RX
65/100Where the value is
- Every commitment tier bundles a dedicated care coach, custom treatment plan, and medical oversight at no extra charge
- Genuine month-to-month option exists with no long-term lock-in, unlike some peers that require prepay
- HSA/FSA eligible with Klarna financing offered
The tradeoffs
- The eye-catching $129/$199 headline prices require a full 12-month prepay ($1,548-$2,388 charged upfront) — the flexible month-to-month rate is $199/$259, notably higher
- No compounding pharmacy is named — only a generic 'certified U.S. pharmacies' claim
PlushCare
65/100Where the value is
- Board-certified physicians (not NP-only) available in all 50 states for general virtual primary care
- Publishes an unusually granular compounded-tirzepatide dose ladder ($399/$599/$749 by vial count) instead of a vague single 'starting at' figure
- Brand Wegovy via NovoCare's manufacturer program can beat most compounded prices ($199-399/mo) when the promotion is genuinely still active
The tradeoffs
- Compounded tirzepatide and semaglutide are each only available in about 39 states plus DC, narrower than PlushCare's general 50-state telehealth business
- A $19.99/mo membership and, for uninsured patients, a $129 visit fee sit on top of every medication price and are easy to miss from the headline drug price alone
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.