Head-to-head · Cost-Efficiency Index
Luma Meds vs Rex MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Luma Meds
Shoppers comfortable starting an intake flow to see real dose-specific pricing, since the public price is a blended promo figure.
Visit Luma MedsRex MD
Cost-first shoppers who want men wanting brand-name Wegovy/Zepbound access through a manufacturer direct-pay bridge, not compounded medication.
Visit Rex MDThe verdict
Luma Meds and Rex MD tie on the Cost-Efficiency Index at 56/100, so neither wins outright on the numbers. For most shoppers we'd start with Luma Meds (ranked #327, a hair above #331) — Shoppers comfortable starting an intake flow to see real dose-specific pricing, since the public price is a blended promo figure. But Rex MD is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Luma Meds.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Luma Meds | Rex MD |
|---|---|---|
| Cost-Efficiency Index | 56/100 | 56/100 |
| Semaglutide / mo | $140/mo (starting dose, compounded) | $574/mo (all doses, plus a separate fee, brand-name) |
| Tirzepatide / mo | $140/mo (starting dose, compounded) | $424/mo (brand Zepbound, plus a separate fee) |
| Semaglutide / yr (modeled) | $1,680 | $6,888 |
| Tirzepatide / yr (modeled) | $1,680 | $5,088 |
| Coverage | Coverage not published | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #327 | #331 |
Luma Meds
56/100Where the value is
- LegitScript Certified seal is present and links to a working verification page
- Clear compliance disclaimers about not practicing medicine directly
- Uses 503A/503B licensed compounding pharmacies per its own policy language
The tradeoffs
- Headline price is a discounted promo ('$50 OFF'), not a transparent baseline rate
- No per-drug (semaglutide vs. tirzepatide) price breakdown visible without starting intake
Rex MD
56/100Where the value is
- Genuine FDA-approved brand-name medication (Wegovy, Zepbound, Saxenda) rather than compounded — a different, more regulated tier than most of this list
- Named medical leadership (Dr. Anthony Puopolo, M.D., Rex MD Affiliated Medical Group) and a LegitScript Certified badge
- Backed by publicly known parent LifeMD, with an established telehealth track record
The tradeoffs
- The headline $75 is NOT the medication cost — Wegovy runs an additional $499/mo (any dose) and Zepbound vials an additional $349/mo, both billed separately by the manufacturer, not Rex MD
- All-in realistic cost is roughly $424-$574/month, far above what a '$75' or even a '$349' headline implies depending on which landing page you see
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.