Head-to-head · Cost-Efficiency Index
Lttl vs Tuyo Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Lttl
Shoppers who want every commitment tier priced openly before intake, and who will read which rung the headline came from.
Visit LttlTuyo Health
Shoppers who want a low advertised floor price and are willing to confirm the actual dose-tier cost before committing.
Visit Tuyo HealthThe verdict
Tuyo Health takes it, leading the Cost-Efficiency Index 57 to 55. Tuyo Health is a compounded-GLP-1 telehealth platform advertising semaglutide from $155/month and tirzepatide from $279/month, with free consultation, same-week shipping and quarterly labs bundled in. Lttl still earns a C — Shoppers who want every commitment tier priced openly before intake, and who will read which rung the headline came from.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Tuyo Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Lttl | Tuyo Health |
|---|---|---|
| Cost-Efficiency Index | 55/100 | 57/100 |
| Semaglutide / mo | $199/mo (compounded) | $155/mo (starting dose, compounded) |
| Tirzepatide / mo | $279/mo (compounded) | $279/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $2,388 | $1,860 |
| Tirzepatide / yr (modeled) | $3,348 | $3,348 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #295 | #298 |
Lttl
55/100Where the value is
- Publishes the full price matrix — every medication, form and commitment length — on a public /plans page before checkout, including the literal "$279/mo every month"
- Named medical advisory board (pharmacist, nurse practitioner, physical therapist) rather than zero disclosure
- Real LegitScript verification badge with a working certificate link
The tradeoffs
- Headline marketing price is a 12-month-prepay rate, not the true month-to-month cost — "Plans start at $129/mo" is $1,548 paid up front
- True cancel-anytime price is $199 semaglutide and $279 tirzepatide, 35–40% above the advertised "from" figures
Tuyo Health
57/100Where the value is
- Quarterly lab work is explicitly bundled into the compounded-track price, unlike sites that omit lab monitoring entirely
- Offers both compounded and branded (insurance-eligible) tracks on the same platform
- LegitScript certified
The tradeoffs
- Both headline prices are explicit 'as low as' floors with no dose-tier table published — the real cost for a titrated-up dose is unknown from the site
- No compounding pharmacy or individual prescriber/medical director named anywhere on the page
Regulatory note: the FDA issued a warning letter to Tuyo Health, Inc. dba Tuyo Health in September 2025. We still list and link to Tuyo Health; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.