Head-to-head · Cost-Efficiency Index
KERNX Health vs Enhance MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
KERNX Health
Shoppers comparing the real cost at their prescribed dose rather than the advertised entry price.
Visit KERNX HealthEnhance MD
Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Visit Enhance MDThe verdict
KERNX Health takes it, leading the Cost-Efficiency Index 79 to 75. KERNX Health serves all 50 states, names its prescribing clinicians individually, and publishes the price of every dose rung — but never says which pharmacy compounds the medication. Enhance MD still earns a C — Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs KERNX Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | KERNX Health | Enhance MD |
|---|---|---|
| Cost-Efficiency Index | 79/100 | 75/100 |
| Semaglutide / mo | $129/mo (compounded) | $212/mo (first month $112) |
| Tirzepatide / mo | $229/mo (compounded) | $280/mo (first month $180) |
| Semaglutide / yr (modeled) | $1,548 | $2,544 |
| Tirzepatide / yr (modeled) | $2,748 | $3,360 |
| Coverage | All 50 states | Not disclosed |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #36 | #43 |
KERNX Health
79/100Where the value is
- Names individual licensed providers (MDs and NPs) with credentials rather than a vague 'our doctors' claim
- Serves all 50 states through a licensed physician network
- Publishes the full dose ladder for both molecules — semaglutide to $199, tirzepatide to $329 — so the cost at a higher dose is knowable before starting
The tradeoffs
- A separate one-time consultation fee of $25 to $60 applies on top of the first month's medication cost
- No specific compounding pharmacy partner is named anywhere public
Enhance MD
75/100Where the value is
- Fully published, dose-flat tiered pricing — sema $212/mo, tirz $280/mo, microdose $169/mo, sema+tirz combo $322/mo — no quiz or quote wall
- The rate does not climb as your dose is titrated up, unlike per-mg pricing elsewhere in this ranking
- Routine lab work at the 6-month mark plus ongoing provider messaging is bundled into the price, not sold separately
The tradeoffs
- Compounded only — no FDA-approved brand-name route (no Wegovy, Ozempic, Mounjaro or Zepbound)
- No oral or sublingual GLP-1 option (injection only)
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.