Head-to-head · Cost-Efficiency Index
Jyra Health vs Nalena
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Jyra Health
Cost-first shoppers who want low compounded GLP-1 pricing if you're comfortable prepaying a 3-month plan.
Visit Jyra HealthNalena
Cost-first shoppers who want women-focused GLP-1-only platform with no membership or hidden fees.
Visit NalenaThe verdict
Jyra Health and Nalena tie on the Cost-Efficiency Index at 74/100, so neither wins outright on the numbers. For most shoppers we'd start with Jyra Health (ranked #59, a hair above #60) — Cost-first shoppers who want low compounded GLP-1 pricing if you're comfortable prepaying a 3-month plan. But Nalena is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Jyra Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Jyra Health | Nalena |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 74/100 |
| Semaglutide / mo | $175/mo (all doses, compounded) | $149/mo (starting dose, compounded) |
| Tirzepatide / mo | $199/mo (all doses, compounded) | $149/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $2,100 | $1,788 |
| Tirzepatide / yr (modeled) | $2,388 | $1,788 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #59 | #60 |
Jyra Health
74/100Where the value is
- Genuine, math-consistent 3-month prepay discount ($111 off semaglutide, $60 off tirzepatide across 3 months) rather than a vague 'up to X% off' claim
- Flat price at every dose with no renewal increase, on both the 1-month and 3-month tiers
- Claims all-50-state coverage with no membership fees and free express delivery
The tradeoffs
- The lower headline-friendly prices ($139/mo semaglutide, $179/mo tirzepatide) are only available by prepaying a full 3-month plan up front, not as a standing month-to-month rate
- No compounding pharmacy is named anywhere on the site
Nalena
74/100Where the value is
- Compounded GLP-1 from $149/mo with medication included — near the floor of the compounded market
- Transparent fee model: no hidden fees, no membership, cancel anytime
- Money-back guarantee — uncommon among compounded telehealths
The tradeoffs
- Per-dose pricing not published — only the 'starting at $149' entry price
- No LegitScript, HIPAA, or NABP badges on public pages
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.