Head-to-head · Cost-Efficiency Index
Invyncible vs Potere Health MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Invyncible
Cost-first shoppers who want compounded GLP-1 combo programs (with B12/glycine) alongside brand Wegovy/Zepbound on one platform.
Visit InvynciblePotere Health MD
Cost-first shoppers who want low-cost, physician-led GLP-1 weight loss without a subscription.
Visit Potere Health MDThe verdict
Invyncible and Potere Health MD tie on the Cost-Efficiency Index at 59/100, so neither wins outright on the numbers. For most shoppers we'd start with Invyncible (ranked #272, a hair above #276) — Cost-first shoppers who want compounded GLP-1 combo programs (with B12/glycine) alongside brand Wegovy/Zepbound on one platform. But Potere Health MD is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Invyncible.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Invyncible | Potere Health MD |
|---|---|---|
| Cost-Efficiency Index | 59/100 | 59/100 |
| Semaglutide / mo | $149/mo (0.45 mg dose, compounded with glycine + B12) | $80/mo (starting dose, compounded) |
| Tirzepatide / mo | $180/mo (2.5 mg weekly, 4-week program, compounded) | $135/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $1,788 | $960 |
| Tirzepatide / yr (modeled) | $2,160 | $1,620 |
| Coverage | 46 states plus DC | 1 state |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #272 | #276 |
Invyncible
59/100Where the value is
- Publishes real itemized dollar prices for eight separate combo programs plus two brand options directly on the site, no signup required, with the mg vial size named in every dose option
- Sells FDA-approved brand Wegovy ($1,750/mo) and Zepbound ($1,540/mo) alongside compounded options
- Names all six compounding pharmacies with street addresses and phone numbers and lets the patient choose which one fills the prescription
The tradeoffs
- Every listed price is shown as a discount off a much higher struck-through 'list' price, and the page invites further negotiation — reads as permanent anchor pricing
- The entry figure is the smallest vial: plain compounded semaglutide runs $192.50, $262.50 and $350 across its three vial sizes, and the FAQ confirms cost rises with dose
Potere Health MD
59/100Where the value is
- Low starting pricing (about $80-$135/month) with no subscription lock-in
- Physician-led by a named MD, not automated messaging
- Third-party COA and LegitScript-certified pharmacy
The tradeoffs
- Available in Utah only — a St George clinic offering telehealth within the state, not a national service
- The per-vial price is fixed, so the monthly cost rises steeply with the dose: the provider's own table runs about $20/mo at 0.25 mg, $80/mo at 1.0 mg and about $199/mo at 2.5 mg
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.