Head-to-head · Cost-Efficiency Index
HelloWellness vs Rex MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
HelloWellness
Cost-first shoppers who want price-sensitive shoppers willing to commit to a 3-month term for a low compounded GLP-1 starting price.
Visit HelloWellnessRex MD
Cost-first shoppers who want men wanting brand-name Wegovy/Zepbound access through a manufacturer direct-pay bridge, not compounded medication.
Visit Rex MDThe verdict
HelloWellness and Rex MD tie on the Cost-Efficiency Index at 56/100, so neither wins outright on the numbers. For most shoppers we'd start with HelloWellness (ranked #324, a hair above #331) — Cost-first shoppers who want price-sensitive shoppers willing to commit to a 3-month term for a low compounded GLP-1 starting price. But Rex MD is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs HelloWellness.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | HelloWellness | Rex MD |
|---|---|---|
| Cost-Efficiency Index | 56/100 | 56/100 |
| Semaglutide / mo | $133/mo (starting dose, 3-month plan, compounded) | $574/mo (all doses, plus a separate fee, brand-name) |
| Tirzepatide / mo | $166/mo (starting dose, 3-month plan, compounded) | $424/mo (brand Zepbound, plus a separate fee) |
| Semaglutide / yr (modeled) | $1,596 | $6,888 |
| Tirzepatide / yr (modeled) | $1,992 | $5,088 |
| Coverage | Coverage not published | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #324 | #331 |
HelloWellness
56/100Where the value is
- $133/mo semaglutide and $166/mo tirzepatide starting prices are among the lowest publicly advertised in the compounded market
- Full refund issued if a patient isn't medically approved, stated plainly on the homepage
- Shipments include syringes, needles, and injection instructions, not just the medication
The tradeoffs
- 3-month minimum commitment — you're billed monthly for all 3 months even if you want to stop after month one
- The LegitScript seal displayed on this site verifies hellowellness.ai, not the hellowellness.health domain it appears on — the certification doesn't clearly cover the site you're ordering from
Rex MD
56/100Where the value is
- Genuine FDA-approved brand-name medication (Wegovy, Zepbound, Saxenda) rather than compounded — a different, more regulated tier than most of this list
- Named medical leadership (Dr. Anthony Puopolo, M.D., Rex MD Affiliated Medical Group) and a LegitScript Certified badge
- Backed by publicly known parent LifeMD, with an established telehealth track record
The tradeoffs
- The headline $75 is NOT the medication cost — Wegovy runs an additional $499/mo (any dose) and Zepbound vials an additional $349/mo, both billed separately by the manufacturer, not Rex MD
- All-in realistic cost is roughly $424-$574/month, far above what a '$75' or even a '$349' headline implies depending on which landing page you see
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.