Head-to-head · Cost-Efficiency Index
HealthRX vs Rylo Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
HealthRX
Shoppers who want the whole term ladder published before intake and are reading it carefully enough to spot which rung the headline came from.
Visit HealthRXRylo Health
Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.
Visit Rylo HealthThe verdict
Rylo Health takes it, leading the Cost-Efficiency Index 75 to 74. Rylo Health is a compounded GLP-1/NAD+/peptide telehealth platform operating in all 50 states through Lone Star Virtual Health PLLC and dispensing via VialsRX in Houston, TX. HealthRX still earns a C — Shoppers who want the whole term ladder published before intake and are reading it carefully enough to spot which rung the headline came from.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Rylo Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | HealthRX | Rylo Health |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 75/100 |
| Semaglutide / mo | $190/mo (all doses, compounded) | $149/mo (all doses, promotional rate, compounded) |
| Tirzepatide / mo | $239/mo (all doses, compounded) | $249/mo (all doses, compounded) |
| Semaglutide / yr (modeled) | $2,280 | $1,788 |
| Tirzepatide / yr (modeled) | $2,868 | $2,988 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #46 | #52 |
HealthRX
74/100Where the value is
- All 50 states, printed in the site's own header strip rather than left to the intake quiz
- Specific, checkable LegitScript certificate number (50087439) rather than just a generic badge image
- "Same price at every dose" policy avoids dose-based price creep
The tradeoffs
- The advertised $99 and $179 are twelve-month prepay rungs — $1,188 and $2,148 up front. The standing month-to-month rates are $190 and $239, roughly double and a third higher
- A second discount is stacked on the same headline: $99 semaglutide and $149 tirzepatide are also first-month intro rates on the monthly plan, so month two costs more than month one
Rylo Health
75/100Where the value is
- Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
- Medication, provider review, and shipping all stated as included in the quoted price with no add-ons found
- Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous
The tradeoffs
- The '$100/$160 First 20 rate' shown prominently on the homepage is limited to the first 20 signups only — most shoppers will pay the higher $149/$249 standard rate, and the promo framing can make the real price look lower than it is
- The advertised 'quarterly $349/$499' option's actual billing mechanics (one-time total vs. recurring monthly-under-commitment) could not be verified — the product pages that would clarify this render via JavaScript and returned no readable pricing text
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.