Head-to-head · Cost-Efficiency Index
He & She MD vs Trillium Meds
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
He & She MD
Shoppers comparing injectable semaglutide specifically, where the advertised $199 genuinely is the standing price — not oral semaglutide or tirzepatide, which roll higher after 6 months.
Visit He & She MDTrillium Meds
Cost-first shoppers who want all-50-state compounded GLP-1 with a real month-to-month option and a cheaper 3-month prepay path.
Visit Trillium MedsThe verdict
Trillium Meds takes it, leading the Cost-Efficiency Index 73 to 71. Trillium Meds is a small, Portland-OR-based telehealth platform connecting patients to independent licensed providers and compounding pharmacies for GLP-1 therapy, serving all 50 states plus Puerto Rico. He & She MD still earns a C — Shoppers comparing injectable semaglutide specifically, where the advertised $199 genuinely is the standing price — not oral semaglutide or tirzepatide, which roll higher after 6 months.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Trillium Meds.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | He & She MD | Trillium Meds |
|---|---|---|
| Cost-Efficiency Index | 71/100 | 73/100 |
| Semaglutide / mo | $199/mo (month to month, compounded; every lower rate is a prepaid term) | $159/mo (all doses, compounded) |
| Tirzepatide / mo | $299/mo (month to month, compounded; every lower rate is a prepaid term) | $249/mo (all doses, compounded) |
| Semaglutide / yr (modeled) | $2,388 | $1,908 |
| Tirzepatide / yr (modeled) | $2,388 | $2,988 |
| Coverage | All states except Louisiana (GLP-1) | All 50 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #65 | #71 |
He & She MD
71/100Where the value is
- Compounded semaglutide and tirzepatide (injectable or oral), with brand-name access to Ozempic, Wegovy, and Zepbound also offered
- Named pharmacy (F&F Pharmacies Inc DBA Jungle Jim's Pharmacy, Fairfield OH) and named CMO (Dr. Ozita Cooper, MD)
- Free expedited shipping and unlimited board-certified clinician access
The tradeoffs
- Its own FAQ says the pharmacy it names holds a license in 44 US states, none in California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia or Delaware, and “cannot dispense sterile compounds” — while the same FAQ says GLP-1s ship everywhere except Louisiana. Injectable GLP-1s are sterile compounds, and the site never says which of its two pharmacies covers the gap
- The uniform '$199 to start' banner across all three tracks obscures that only injectable semaglutide holds at $199 ongoing — oral semaglutide rolls to $239/mo and injectable tirzepatide rolls to $289/mo after the first 6-month cycle
Trillium Meds
73/100Where the value is
- Discloses both a real month-to-month rate ($159/$249) and the 3-month prepay rate, rather than only advertising the lower prepay number
- LegitScript certified, all 50 states plus Puerto Rico, with a real street address published
- Syringes and alcohol wipes included; Klarna and Affirm financing available
The tradeoffs
- The lowest advertised rate ($119/mo semaglutide, ~$200/mo tirzepatide) requires a $357 or $599 upfront 3-month payment, not a standing monthly charge
- Partner pharmacy names are referenced in the FAQ structure but were not visible in the page text pulled this session — re-verify before citing a specific pharmacy
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.