Head-to-head · Cost-Efficiency Index
He & She MD vs Amazon One Medical
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
He & She MD
Shoppers comparing injectable semaglutide specifically, where the advertised $199 genuinely is the standing price — not oral semaglutide or tirzepatide, which roll higher after 6 months.
Visit He & She MDAmazon One Medical
Patients who specifically want a real FDA-approved branded medication (Wegovy, Zepbound, or Foundayo) rather than a compounded alternative, and already shop on Amazon.
Visit Amazon One MedicalThe verdict
Amazon One Medical takes it, leading the Cost-Efficiency Index 73 to 71. Amazon One Medical's GLP-1 program (health.amazon.com/onemedical) is a branded-only prescribing service it will not write compounded prescriptions that charges a separate ~$39 initial care fee from the medication cost itself. He & She MD still earns a C — Shoppers comparing injectable semaglutide specifically, where the advertised $199 genuinely is the standing price — not oral semaglutide or tirzepatide, which roll higher after 6 months.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Amazon One Medical.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | He & She MD | Amazon One Medical |
|---|---|---|
| Cost-Efficiency Index | 71/100 | 73/100 |
| Semaglutide / mo | $199/mo (month to month, compounded; every lower rate is a prepaid term) | $299/mo (brand Wegovy, plus a separate fee) |
| Tirzepatide / mo | $299/mo (month to month, compounded; every lower rate is a prepaid term) | $299/mo (brand Zepbound) |
| Semaglutide / yr (modeled) | $2,388 | $3,588 |
| Tirzepatide / yr (modeled) | $2,388 | $3,588 |
| Coverage | All states except Louisiana (GLP-1) | All 50 states |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Yes | Yes |
| Rank here | #65 | #67 |
He & She MD
71/100Where the value is
- Compounded semaglutide and tirzepatide (injectable or oral), with brand-name access to Ozempic, Wegovy, and Zepbound also offered
- Named pharmacy (F&F Pharmacies Inc DBA Jungle Jim's Pharmacy, Fairfield OH) and named CMO (Dr. Ozita Cooper, MD)
- Free expedited shipping and unlimited board-certified clinician access
The tradeoffs
- Its own FAQ says the pharmacy it names holds a license in 44 US states, none in California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia or Delaware, and “cannot dispense sterile compounds” — while the same FAQ says GLP-1s ship everywhere except Louisiana. Injectable GLP-1s are sterile compounds, and the site never says which of its two pharmacies covers the gap
- The uniform '$199 to start' banner across all three tracks obscures that only injectable semaglutide holds at $199 ongoing — oral semaglutide rolls to $239/mo and injectable tirzepatide rolls to $289/mo after the first 6-month cycle
Amazon One Medical
73/100Where the value is
- Prescribes only FDA-approved branded medications — no compounded product risk, which in this ranking only LillyDirect also avoids
- Same-day medication delivery available in roughly 3,000 cities via Amazon Pharmacy's existing logistics network
- One Medical membership is explicitly optional, not a gate, to access GLP-1 care
The tradeoffs
- The care fee (~$39-$49) and the medication cost are billed completely separately — the site itself warns 'the cost of your prescribed medication is not included with the treatment price,' so no single headline number captures the real all-in cost
- The lowest advertised Rx price ('$149 with coupon if eligible') is conditional on manufacturer coupon eligibility, not guaranteed to every patient
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.