Head-to-head · Cost-Efficiency Index
Genesis Health vs Defy Medical
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Genesis Health
Shoppers comparing multi-category telehealth (weight loss + sexual health + anti-aging) willing to prepay or finance to unlock the lowest listed rate.
Visit Genesis HealthDefy Medical
Cost-first shoppers who want existing or prospective TRT/men's-health patients wanting to add GLP-1 to an established hormone-optimization relationship -- not the first stop for a shopper solely comparing dedicated GLP-1 weight-loss pricing.
Visit Defy MedicalThe verdict
Genesis Health and Defy Medical tie on the Cost-Efficiency Index at 43/100, so neither wins outright on the numbers. For most shoppers we'd start with Genesis Health (ranked #489, a hair above #492) — Shoppers comparing multi-category telehealth (weight loss + sexual health + anti-aging) willing to prepay or finance to unlock the lowest listed rate. But Defy Medical is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Genesis Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Genesis Health | Defy Medical |
|---|---|---|
| Cost-Efficiency Index | 43/100 | 43/100 |
| Semaglutide / mo | Not disclosed | Not disclosed |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | — | — |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | Yes |
| Brand-name access | Yes | Compounded only |
| Rank here | #489 | #492 |
Genesis Health
43/100Where the value is
- Offers both compounded and FDA-approved branded GLP-1 options (Ozempic, Wegovy, Zepbound) in one place
- Buy-now-pay-later financing available for those who can't pay a lump sum upfront
- Multi-category platform (weight loss, sexual health, anti-aging) for one-stop telehealth shopping
The tradeoffs
- Headline '$176/mo' price is explicitly a 2-month-prepay-or-financed rate, not a real month-to-month price
- No medical director, compounding pharmacy, or state-coverage list disclosed
Regulatory note: the FDA issued a warning letter to Genesis Health International Inc. dba Genesis in February 2026. We still list and link to Genesis Health; you should know the letter is on the public record before you decide.
Defy Medical
43/100Where the value is
- Named, credentialed Medical Director (Dr. Justin Saya)
- Large third-party review base (3,999 Trustpilot reviews, 5-star average)
- Offers both semaglutide and tirzepatide alongside broader men's-health services
The tradeoffs
- GLP-1 is clearly a secondary offering bolted onto a primarily TRT/hormone-optimization practice, not its core focus
- Zero pricing disclosed anywhere on the public site -- fully gated behind quiz/consultation
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.