Head-to-head · Cost-Efficiency Index
FMmeds vs Sipra
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
FMmeds
Cost-first shoppers who want a genuinely all-in flat monthly price that doesn't rise as your dose increases.
Visit FMmedsSipra
Shoppers ready to commit to at least three months who want a price that doesn't rise with the dose and a full price table before they start.
Visit SipraThe verdict
FMmeds and Sipra tie on the Cost-Efficiency Index at 78/100, so neither wins outright on the numbers, so choose on fit. FMmeds: Cost-first shoppers who want a genuinely all-in flat monthly price that doesn't rise as your dose increases. Sipra: Shoppers ready to commit to at least three months who want a price that doesn't rise with the dose and a full price table before they start.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs FMmeds.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | FMmeds | Sipra |
|---|---|---|
| Cost-Efficiency Index | 78/100 | 78/100 |
| Semaglutide / mo | $95/moAll doses, plus a separate fee, compounded | $189/mo3-month plan, $567 charged up front, same price at every dose, compounded |
| Tirzepatide / mo | $145/moAll doses, plus a separate fee, compounded | $249/mo3-month plan, $747 charged up front, same price at every dose, compounded |
| Semaglutide / yr (modeled) | $1,140 | $2,268 |
| Tirzepatide / yr (modeled) | $1,740 | $2,988 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #48 | #52 |
FMmeds
78/100Where the value is
- The advertised price is confirmed all-in on the site's own FAQ (visit, physician review, and medication), not a bare medication cost
- Explicitly flat regardless of dose escalation — a real, published guarantee, not just a claim
- Named 503A compounding pharmacy (Manifest Pharmacy) and a real support phone/email
The tradeoffs
- Compounded only — not FDA-approved, and the site carries the standard compounded-medication disclaimer
- The site doesn't list the states it serves, show a LegitScript badge or name its prescribers
Sipra
78/100Where the value is
- A full price table by drug and plan length is published, and the price stays the same as your dose goes up
- Your card isn't charged until a licensed physician reviews and approves your treatment
- Injections, lower-dose microdose injections and dissolving tablets are all offered for both drugs
The tradeoffs
- There's no month-to-month option for GLP-1s: the shortest plan is three months, charged in one payment ($567 for semaglutide, $747 for tirzepatide)
- To stop the next order you have to cancel at least 13 days before your paid period ends
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.