Head-to-head · Cost-Efficiency Index
FMmeds vs Enhance MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
FMmeds
Cost-first shoppers who want a genuinely all-in flat monthly price that doesn't rise as your dose increases.
Visit FMmedsEnhance MD
Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Visit Enhance MDThe verdict
FMmeds takes it, leading the Cost-Efficiency Index 78 to 75. FMmeds is a compounded-GLP-1 telehealth membership selling semaglutide from $95/mo and tirzepatide from $145/mo, both co-formulated with Vitamin B12 and dispensed by Manifest Pharmacy. Enhance MD still earns a C — Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs FMmeds.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | FMmeds | Enhance MD |
|---|---|---|
| Cost-Efficiency Index | 78/100 | 75/100 |
| Semaglutide / mo | $95/mo (all doses, plus a separate fee, compounded) | $212/mo (first month $112) |
| Tirzepatide / mo | $145/mo (all doses, plus a separate fee, compounded) | $280/mo (first month $180) |
| Semaglutide / yr (modeled) | $1,140 | $2,544 |
| Tirzepatide / yr (modeled) | $1,740 | $3,360 |
| Coverage | All 50 states | Not disclosed |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #41 | #43 |
FMmeds
78/100Where the value is
- The advertised price is confirmed all-in on the site's own FAQ (visit, physician review, and medication), not a bare medication cost
- Explicitly flat regardless of dose escalation — a real, published guarantee, not just a claim
- Named 503A compounding pharmacy (Manifest Pharmacy) and a real support phone/email
The tradeoffs
- Compounded only — not FDA-approved, and the site carries the standard compounded-medication disclaimer
- No states-served list, LegitScript badge, or named prescriber/medical director found on the pages read this session
Enhance MD
75/100Where the value is
- Fully published, dose-flat tiered pricing — sema $212/mo, tirz $280/mo, microdose $169/mo, sema+tirz combo $322/mo — no quiz or quote wall
- The rate does not climb as your dose is titrated up, unlike per-mg pricing elsewhere in this ranking
- Routine lab work at the 6-month mark plus ongoing provider messaging is bundled into the price, not sold separately
The tradeoffs
- Compounded only — no FDA-approved brand-name route (no Wegovy, Ozempic, Mounjaro or Zepbound)
- No oral or sublingual GLP-1 option (injection only)
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.