Head-to-head · Cost-Efficiency Index
Enhance MD vs SurpassMD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Enhance MD
Shoppers who want flat pricing that doesn't rise with the dose, routine lab monitoring and a semaglutide-plus-tirzepatide combo option, and who don't need a brand-name or oral route.
Visit Enhance MDSurpassMD
Shoppers who want a published price table by plan length and a price that stays put as the dose goes up.
Visit SurpassMDThe verdict
SurpassMD takes it, leading the Cost-Efficiency Index 78 to 76. SurpassMD's standing month-to-month rate is $219 for compounded semaglutide and $309 for tirzepatide, all-in and the same at every dose; the $114 and $177 on its homepage are introductory 12-month rates. Enhance MD still earns a C — Shoppers who want flat pricing that doesn't rise with the dose, routine lab monitoring and a semaglutide-plus-tirzepatide combo option, and who don't need a brand-name or oral route.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs SurpassMD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Enhance MD | SurpassMD |
|---|---|---|
| Cost-Efficiency Index | 76/100 | 78/100 |
| Semaglutide / mo | $212/moFirst month $112 | $219/moCompounded, month to month; $175 introductory first month, same price at every dose |
| Tirzepatide / mo | $280/moFirst month $180 | $309/moCompounded, month to month; $247 introductory first month, same price at every dose |
| Semaglutide / yr (modeled) | $2,544 | $2,628 |
| Tirzepatide / yr (modeled) | $3,360 | $3,708 |
| Coverage | 40 states + DC | All 50 states and D.C. |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #45 | #50 |
Enhance MD
76/100Where the value is
- Every plan is priced on the homepage before any quiz: semaglutide $212, tirzepatide $280, a semaglutide-plus-tirzepatide combo $322 and microdosed tirzepatide $169
- The monthly price stays the same as your dose goes up
- Lab testing every six months and ongoing provider messaging are built into the price rather than sold separately
The tradeoffs
- Compounded only, with no brand-name Wegovy, Ozempic, Mounjaro or Zepbound
- No oral or sublingual GLP-1, so every option is an injection
SurpassMD
78/100Where the value is
- Each medication page has a full table of 1-, 3-, 6- and 12-month prices, showing both the introductory rate and the standard renewal rate
- One price covers the provider review, medication, shipping and ongoing support, with no separate membership fee
- The price does not rise when your provider increases your dose
The tradeoffs
- The homepage's "as low as $114" and "$177" are introductory prices on a 12-month supply; month to month the standard rates are $219 and $309
- No refunds after cancellation unless you're medically disqualified
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.