Head-to-head · Cost-Efficiency Index
Enhance MD vs Sipra
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Enhance MD
Shoppers who want flat pricing that doesn't rise with the dose, routine lab monitoring and a semaglutide-plus-tirzepatide combo option, and who don't need a brand-name or oral route.
Visit Enhance MDSipra
Shoppers ready to commit to at least three months who want a price that doesn't rise with the dose and a full price table before they start.
Visit SipraThe verdict
Sipra takes it, leading the Cost-Efficiency Index 78 to 76. Sipra's shortest GLP-1 plan is three months paid up front: $189 a month for compounded semaglutide and $249 for tirzepatide, the same at every dose, with nothing charged until a physician approves. Enhance MD still earns a C — Shoppers who want flat pricing that doesn't rise with the dose, routine lab monitoring and a semaglutide-plus-tirzepatide combo option, and who don't need a brand-name or oral route.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Sipra.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Enhance MD | Sipra |
|---|---|---|
| Cost-Efficiency Index | 76/100 | 78/100 |
| Semaglutide / mo | $212/moFirst month $112 | $189/mo3-month plan, $567 charged up front, same price at every dose, compounded |
| Tirzepatide / mo | $280/moFirst month $180 | $249/mo3-month plan, $747 charged up front, same price at every dose, compounded |
| Semaglutide / yr (modeled) | $2,544 | $2,268 |
| Tirzepatide / yr (modeled) | $3,360 | $2,988 |
| Coverage | 40 states + DC | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #45 | #52 |
Enhance MD
76/100Where the value is
- Every plan is priced on the homepage before any quiz: semaglutide $212, tirzepatide $280, a semaglutide-plus-tirzepatide combo $322 and microdosed tirzepatide $169
- The monthly price stays the same as your dose goes up
- Lab testing every six months and ongoing provider messaging are built into the price rather than sold separately
The tradeoffs
- Compounded only, with no brand-name Wegovy, Ozempic, Mounjaro or Zepbound
- No oral or sublingual GLP-1, so every option is an injection
Sipra
78/100Where the value is
- A full price table by drug and plan length is published, and the price stays the same as your dose goes up
- Your card isn't charged until a licensed physician reviews and approves your treatment
- Injections, lower-dose microdose injections and dissolving tablets are all offered for both drugs
The tradeoffs
- There's no month-to-month option for GLP-1s: the shortest plan is three months, charged in one payment ($567 for semaglutide, $747 for tirzepatide)
- To stop the next order you have to cancel at least 13 days before your paid period ends
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.