Head-to-head · Cost-Efficiency Index
Enhance MD vs Pallas Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Enhance MD
Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Visit Enhance MDPallas Health
Shoppers comfortable paying a quarter at a time who want the whole cost stated before signup, and who are not looking for a month-to-month exit.
Visit Pallas HealthThe verdict
Enhance MD takes it, leading the Cost-Efficiency Index 75 to 74. The clearest tiered price ladder in this ranking — separate published lines for semaglutide, tirzepatide, a microdose tier and a sema+tirz combo — with lab work built into every tier. Pallas Health still earns a C — Shoppers comfortable paying a quarter at a time who want the whole cost stated before signup, and who are not looking for a month-to-month exit.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Enhance MD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Enhance MD | Pallas Health |
|---|---|---|
| Cost-Efficiency Index | 75/100 | 74/100 |
| Semaglutide / mo | $212/mo (first month $112) | $199/mo average — Pallas's own figure for $597 billed every 12 weeks, its only cadence; $139 covers the first 4 weeks |
| Tirzepatide / mo | $280/mo (first month $180) | $299/mo average — Pallas's own figure for $897 billed every 12 weeks, its only cadence; $179 covers the first 4 weeks |
| Semaglutide / yr (modeled) | $2,544 | $2,388 |
| Tirzepatide / yr (modeled) | $3,360 | $3,588 |
| Coverage | Not disclosed | Most states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #39 | #42 |
Enhance MD
75/100Where the value is
- Fully published, dose-flat tiered pricing — sema $212/mo, tirz $280/mo, microdose $169/mo, sema+tirz combo $322/mo — no quiz or quote wall
- The rate does not climb as your dose is titrated up, unlike per-mg pricing elsewhere in this ranking
- Routine lab work at the 6-month mark plus ongoing provider messaging is bundled into the price, not sold separately
The tradeoffs
- Compounded only — no FDA-approved brand-name route (no Wegovy, Ozempic, Mounjaro or Zepbound)
- No oral or sublingual GLP-1 option (injection only)
Pallas Health
74/100Where the value is
- Both molecules are priced publicly, with the charged block stated rather than only a monthly average
- A genuinely reduced first cycle — $139 semaglutide and $179 tirzepatide for the first four weeks
- Runs a Spanish-language lander as well as the English site, which most of this field does not
The tradeoffs
- There is no monthly rung. The only cadence is a 12-week block paid up front — $597 or $897 — so the advertised 'per month' figure is arithmetic rather than a payment anyone makes
- A 12-week cycle is 4.33 charges a year, not 4, so a year costs more than four times the block
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.