Head-to-head · Cost-Efficiency Index
Collective vs Fifty 410
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Collective
Shoppers who will stay on treatment for a full year, where the annual membership divides down over twelve months rather than landing on one.
Visit CollectiveFifty 410
Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Visit Fifty 410The verdict
Fifty 410 takes it, leading the Cost-Efficiency Index 59 to 57. Fifty 410 is a direct-to-consumer compounded-GLP-1 telehealth service. Collective still earns a C — Shoppers who will stay on treatment for a full year, where the annual membership divides down over twelve months rather than landing on one.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Fifty 410.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Collective | Fifty 410 |
|---|---|---|
| Cost-Efficiency Index | 57/100 | 59/100 |
| Semaglutide / mo | $59/mo for the medication, plus a required $199/year membership billed separately | $199/mo (all doses, compounded) |
| Tirzepatide / mo | $69/mo for the medication, plus the same required $199/year membership | $133/mo (starting dose, 3-month plan, compounded) |
| Semaglutide / yr (modeled) | $708 | $2,388 |
| Tirzepatide / yr (modeled) | $828 | $1,596 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #262 | #263 |
Collective
57/100Where the value is
- Both figures are medication prices rather than a care fee with the drug billed on top, and both appear before any intake
- The membership covers unlimited doctor messaging, check-ins, dose adjustments, nutrition support and express cold shipping, all itemized
- A 21-day free trial precedes the first membership charge, and the trial's auto-conversion is stated plainly
The tradeoffs
- The headline "Get GLP-1s at $59/month" leaves out the mandatory $199 annual membership, which appears only in a card panel, a small disclaimer and the FAQ
- The membership is annual and auto-renewing, and all membership fees are non-refundable with no partial-period refund — so the cheapest medication price here cannot be bought for one month
Fifty 410
59/100Where the value is
- No recurring subscription — you pay once per order and are not auto-billed
- Transparent per-tier tirzepatide totals ($399/$499/$549) shown alongside the per-month math, so the real charge is visible if you read past the headline
- Free overnight/2-day shipping and refrigerated packaging included in every tier
The tradeoffs
- Tirzepatide's advertised '$133/month' is a 3-month prepay of $399 charged in one transaction, not a monthly recurring price — the cheapest advertised number is not what most shoppers will assume
- Semaglutide has no discounted multi-month tier and, at $199 flat, actually costs more per month than tirzepatide's cheapest bundle
Regulatory note: the FDA issued a warning letter to Aspen Aesthetics dba Fifty 410 in February 2026. We still list and link to Fifty 410; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.