Head-to-head · Cost-Efficiency Index
Cielo vs Tryozi
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Cielo
Shoppers comfortable committing to an undisclosed-structure 6-month plan for a flat, dose-independent price.
Visit CieloTryozi
Shoppers comparing standing rates rather than first-month promo banners.
Visit TryoziThe verdict
Cielo and Tryozi tie on the Cost-Efficiency Index at 68/100, so neither wins outright on the numbers. For most shoppers we'd start with Cielo (ranked #115, a hair above #121) — Shoppers comfortable committing to an undisclosed-structure 6-month plan for a flat, dose-independent price. But Tryozi is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Cielo.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Cielo | Tryozi |
|---|---|---|
| Cost-Efficiency Index | 68/100 | 68/100 |
| Semaglutide / mo | $89/mo (all doses, 6-month plan, compounded) | $279/mo (first-month rate, compounded) |
| Tirzepatide / mo | $129/mo (all doses, 6-month plan, compounded) | $379/mo (first-month rate, compounded) |
| Semaglutide / yr (modeled) | $1,068 | $3,348 |
| Tirzepatide / yr (modeled) | $1,548 | $4,548 |
| Coverage | Coverage not published | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Yes | Yes |
| Rank here | #115 | #121 |
Cielo
68/100Where the value is
- Flat pricing regardless of dose for both semaglutide and tirzepatide, avoiding per-mg price escalation during titration
- Free physician consult and free shipping stated as included
- Claims 'Every batch tested', at least asserting quality-control testing exists
The tradeoffs
- The '6-month plan' mechanics are never explained — whether it's a one-time prepayment or a 6-month billing lock is unknown, which is exactly the kind of commitment term that should be disclosed before signup
- No pharmacy, medical director, or prescriber is named anywhere on the accessible site
Tryozi
68/100Where the value is
- The site voluntarily discloses its own standing rate ('normally $279/mo') right beside the promo price, which is more transparent than providers that hide it until checkout
- Base labs, consult, medication, and shipping stated as bundled with no hidden fees
- Four named 503A compounding pharmacies rather than one anonymous partner
The tradeoffs
- The prominent $139/$189 banner price is a one-time 50%-off first month only — the real ongoing cost is exactly double, $279/$379/month
- No named individual prescriber or medical director found on the site
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.