Head-to-head · Cost-Efficiency Index
Cielo vs RxPros
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Cielo
Shoppers comfortable committing to an undisclosed-structure 6-month plan for a flat, dose-independent price.
Visit CieloRxPros
Shoppers who want the lowest ongoing per-month compounded rate and don't mind a higher-priced first order.
Visit RxProsThe verdict
Cielo and RxPros tie on the Cost-Efficiency Index at 68/100, so neither wins outright on the numbers. For most shoppers we'd start with Cielo (ranked #115, a hair above #120) — Shoppers comfortable committing to an undisclosed-structure 6-month plan for a flat, dose-independent price. But RxPros is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Cielo.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Cielo | RxPros |
|---|---|---|
| Cost-Efficiency Index | 68/100 | 68/100 |
| Semaglutide / mo | $89/mo (all doses, 6-month plan, compounded) | $100/mo (all doses, compounded) |
| Tirzepatide / mo | $129/mo (all doses, 6-month plan, compounded) | $145/mo (all doses, compounded) |
| Semaglutide / yr (modeled) | $1,068 | $1,200 |
| Tirzepatide / yr (modeled) | $1,548 | $1,740 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #115 | #120 |
Cielo
68/100Where the value is
- Flat pricing regardless of dose for both semaglutide and tirzepatide, avoiding per-mg price escalation during titration
- Free physician consult and free shipping stated as included
- Claims 'Every batch tested', at least asserting quality-control testing exists
The tradeoffs
- The '6-month plan' mechanics are never explained — whether it's a one-time prepayment or a 6-month billing lock is unknown, which is exactly the kind of commitment term that should be disclosed before signup
- No pharmacy, medical director, or prescriber is named anywhere on the accessible site
RxPros
68/100Where the value is
- Flat recurring price of $99.97/mo (sema) and $144.97/mo (tirz) — no per-mg price increase as you titrate up doses
- No membership fee and no mandatory commitment despite an annual-prepay discount option — 'Cancel Subscription Anytime' stated directly
- Ships a 3-month supply per order rather than monthly reshipments
The tradeoffs
- The advertised $99.97/mo (sema) and $144.97/mo (tirz) rates are NOT what a first-time buyer pays — the actual first order is $149 and $249 respectively, 49-72% higher than the headline
- Specific pharmacy partner is not named — a proprietary system routes among unnamed 503A pharmacies and 'cannot guarantee' which one fills any given order
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.