Head-to-head · Cost-Efficiency Index
Amazon One Medical vs MyFastRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Amazon One Medical
Patients who specifically want a real FDA-approved branded medication (Wegovy, Zepbound, or Foundayo) rather than a compounded alternative, and already shop on Amazon.
Visit Amazon One MedicalMyFastRx
Cost-first shoppers who want cash-pay shoppers comfortable prepaying several months upfront to reach the lowest per-month compounded-GLP-1 rate on the market.
Visit MyFastRxThe verdict
Amazon One Medical and MyFastRx tie on the Cost-Efficiency Index at 73/100, so neither wins outright on the numbers. For most shoppers we'd start with Amazon One Medical (ranked #67, a hair above #68) — Patients who specifically want a real FDA-approved branded medication (Wegovy, Zepbound, or Foundayo) rather than a compounded alternative, and already shop on Amazon. But MyFastRx is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Amazon One Medical.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Amazon One Medical | MyFastRx |
|---|---|---|
| Cost-Efficiency Index | 73/100 | 73/100 |
| Semaglutide / mo | $299/mo (brand Wegovy, plus a separate fee) | $139/mo (all doses, promotional rate, compounded) |
| Tirzepatide / mo | $299/mo (brand Zepbound) | $199/mo (all doses, promotional rate, compounded) |
| Semaglutide / yr (modeled) | $3,588 | $1,668 |
| Tirzepatide / yr (modeled) | $3,588 | $2,388 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #67 | #68 |
Amazon One Medical
73/100Where the value is
- Prescribes only FDA-approved branded medications — no compounded product risk, which in this ranking only LillyDirect also avoids
- Same-day medication delivery available in roughly 3,000 cities via Amazon Pharmacy's existing logistics network
- One Medical membership is explicitly optional, not a gate, to access GLP-1 care
The tradeoffs
- The care fee (~$39-$49) and the medication cost are billed completely separately — the site itself warns 'the cost of your prescribed medication is not included with the treatment price,' so no single headline number captures the real all-in cost
- The lowest advertised Rx price ('$149 with coupon if eligible') is conditional on manufacturer coupon eligibility, not guaranteed to every patient
MyFastRx
73/100Where the value is
- Publishes a full, specific price ladder (1/3/6/12-month) rather than a single vague 'starting at' figure
- LegitScript certified
- Flat pricing across all doses — no dosage upcharges as you titrate
The tradeoffs
- The true no-commitment monthly rate ($139 sema / $199 tirz) is meaningfully higher than the deep prepay-bundle rates the marketing emphasizes ($79-99 / $124-166) — those low numbers require paying for 3, 6, or 12 months upfront
- The lowest first-month price ($69 / $129) requires entering a promo code and applies to one month only
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.