Head-to-head · Cost-Efficiency Index
Amazon One Medical vs Clume Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Amazon One Medical
Patients who specifically want a real FDA-approved branded medication (Wegovy, Zepbound, or Foundayo) rather than a compounded alternative, and already shop on Amazon.
Visit Amazon One MedicalClume Health
Readers who want the dispensing pharmacies named up front and do not need the price broken out by molecule.
Visit Clume HealthThe verdict
Amazon One Medical and Clume Health tie on the Cost-Efficiency Index at 73/100, so neither wins outright on the numbers. For most shoppers we'd start with Amazon One Medical (ranked #61, a hair above #66) — Patients who specifically want a real FDA-approved branded medication (Wegovy, Zepbound, or Foundayo) rather than a compounded alternative, and already shop on Amazon. But Clume Health is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Amazon One Medical.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Amazon One Medical | Clume Health |
|---|---|---|
| Cost-Efficiency Index | 73/100 | 73/100 |
| Semaglutide / mo | $299/mo (brand Wegovy, plus a separate fee) | $259/month month-to-month (one Signature price covers semaglutide or tirzepatide, oral or injectable; $186/mo needs a 52-week plan) |
| Tirzepatide / mo | $299/mo (brand Zepbound) | $259/month month-to-month (the same Signature price; $186/mo needs a 52-week plan) |
| Semaglutide / yr (modeled) | $3,588 | $3,108 |
| Tirzepatide / yr (modeled) | $3,588 | $3,108 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Yes | Compounded only |
| Rank here | #61 | #66 |
Amazon One Medical
73/100Where the value is
- Prescribes only FDA-approved branded medications — no compounded product risk, which in this ranking only LillyDirect also avoids
- Same-day medication delivery available in roughly 3,000 cities via Amazon Pharmacy's existing logistics network
- One Medical membership is explicitly optional, not a gate, to access GLP-1 care
The tradeoffs
- The care fee (~$39-$49) and the medication cost are billed completely separately — the site itself warns 'the cost of your prescribed medication is not included with the treatment price,' so no single headline number captures the real all-in cost
- The lowest advertised Rx price ('$149 with coupon if eligible') is conditional on manufacturer coupon eligibility, not guaranteed to every patient
Clume Health
73/100Where the value is
- Names all four dispensing pharmacies with street addresses, phone numbers and websites, so a buyer can look up who actually compounds the prescription
- The price is published before the intake and covers the consultation, ongoing oversight, the medication and delivery
- One figure covers semaglutide, tirzepatide, oral and injectable, so switching molecule or route does not change the bill
The tradeoffs
- Both headline prices on the homepage match nothing on sale: "*$199/month" against real floors of $259 and $219, and "*$159/month" against $216 — and neither asterisk resolves to a footnote
- The cheaper monthly figures are commitments rather than rates: $186 a month requires a 52-week plan and $200 a month a 12-week one
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.