Head-to-head · Cost-Efficiency Index
AlyveRx vs Brello Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
AlyveRx
Shoppers who specifically want a needle-free sublingual GLP-1 option alongside standard injections on the same platform.
Visit AlyveRxBrello Health
Shoppers comfortable with a mandatory 3-month auto-renewing commitment in exchange for a discounted per-month rate.
Visit Brello HealthThe verdict
AlyveRx and Brello Health tie on the Cost-Efficiency Index at 64/100, so neither wins outright on the numbers. For most shoppers we'd start with AlyveRx (ranked #173, a hair above #175) — Shoppers who specifically want a needle-free sublingual GLP-1 option alongside standard injections on the same platform. But Brello Health is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs AlyveRx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | AlyveRx | Brello Health |
|---|---|---|
| Cost-Efficiency Index | 64/100 | 64/100 |
| Semaglutide / mo | $183/mo (starting dose, compounded) | $133/mo (3-month plan, compounded) |
| Tirzepatide / mo | $283/mo (starting dose, compounded) | $166/mo (3-month plan, compounded) |
| Semaglutide / yr (modeled) | $2,196 | $1,596 |
| Tirzepatide / yr (modeled) | $3,396 | $1,992 |
| Coverage | Coverage not published | 35 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #173 | #175 |
AlyveRx
64/100Where the value is
- Offers a genuinely needle-free sublingual delivery option (PermeAct) for both semaglutide and tirzepatide, not just injections
- Also carries brand-name Ozempic, Wegovy, and Mounjaro for patients who want an FDA-approved product
- All four price points (injection and drops, both drugs) are published upfront on the homepage before intake
The tradeoffs
- The dataset's previous $249/mo tirzepatide figure is the SUBLINGUAL DROPS price, not the standard injection ($283/mo) — confirm which form a quoted price refers to
- Sublingual PermeAct absorption relies on the company's own proprietary technology claims and is not FDA-reviewed for weight-loss efficacy
Brello Health
64/100Where the value is
- Discount structure is itemized transparently — both the discounted and pre-discount standing price are shown side by side ($133 vs $198 for semaglutide, $166 vs $247 for tirzepatide)
- Bundle options combining GLP-1 with NAD+ and/or Sermorelin are available on the same subscription
- The commitment mechanics are explicitly disclosed on-site ('3-month minimum commitment and automatically renew every 11 weeks') rather than buried in terms of service
The tradeoffs
- No month-to-month option exists at any price — every plan requires a 3-month minimum and auto-renews every 11 weeks, a real commitment a shopper comparing 'per month' prices across sites could easily miss
- The compounding pharmacy is not named, only 'USA-based 503A Partner Pharmacy,' and the site discloses it is mid-transition to a new facility
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.