Head-to-head · Cost-Efficiency Index
Yucca Health vs Trellis Vitality
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Yucca Health
Shoppers who want a flat monthly price that won't rise as the dose goes up, with the option to pause instead of cancel.
Visit Yucca HealthTrellis Vitality
Shoppers who want a low month-to-month GLP-1 price that holds at every dose, with no membership or consultation fee.
Visit Trellis VitalityThe verdict
Yucca Health takes it, leading the Cost-Efficiency Index 83 to 82. Yucca Health charges $146 a month for compounded semaglutide and $258 for tirzepatide with no commitment, the same at every dose, and refunds six months of payments if you follow the plan and don't lose weight. Trellis Vitality still earns a B− — Shoppers who want a low month-to-month GLP-1 price that holds at every dose, with no membership or consultation fee.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Yucca Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Yucca Health | Trellis Vitality |
|---|---|---|
| Cost-Efficiency Index | 83/100 | 82/100 |
| Semaglutide / mo | $146/moMonth to month, same price at every dose, compounded | $150/moCompounded, month to month; same price at every dose |
| Tirzepatide / mo | $258/moMonth to month, same price at every dose, compounded | $199/moCompounded, month to month; same price at every dose |
| Semaglutide / yr (modeled) | $1,752 | $1,800 |
| Tirzepatide / yr (modeled) | $3,096 | $2,388 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #23 | #29 |
Yucca Health
83/100Where the value is
- Each product page shows all three plans: semaglutide is $146 month to month, $140 a month on three months ($420) and $125 on six ($750); tirzepatide is $258, $248 ($744) and $225 ($1,350)
- The price is locked at every dose for as long as your plan stays active, and pausing keeps the lock
- A written six-month promise refunds everything you paid, including medication, if you follow the plan for six months and haven't lost weight from your logged starting weight
The tradeoffs
- The "$125/mo for life" banner is the six-month plan, billed $750 up front; the no-commitment monthly price is $146
- Once a clinician issues your prescription that order is final and can't be refunded, and you must cancel at least 7 days before a renewal to stop it
Trellis Vitality
82/100Where the value is
- A single table shows one-, three- and six-month prices for both drugs, labeled as per-month prices: semaglutide $150, $140 and $133; tirzepatide $199, $189 and $179
- Same price at every dose, so your cost doesn't rise as you titrate up
- No membership fee, no consultation fee, and you can pause or cancel any time
The tradeoffs
- Its NAD+, glutathione, lipo-MIC and tesamorelin programs show only "starting at" prices with no plan table
- The refund policy says only that refunds are decided order by order
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.