Head-to-head · Cost-Efficiency Index
Yucca Health vs Brightmeds
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Yucca Health
Shoppers who want a flat monthly price that won't rise as the dose goes up, with the option to pause instead of cancel.
Visit Yucca HealthBrightmeds
Shoppers who want a low flat price at every dose on compounded semaglutide or tirzepatide, with the option to save more on a three-month pack.
Visit BrightmedsThe verdict
Yucca Health takes it, leading the Cost-Efficiency Index 83 to 82. Yucca Health charges $146 a month for compounded semaglutide and $258 for tirzepatide with no commitment, the same at every dose, and refunds six months of payments if you follow the plan and don't lose weight. Brightmeds still earns a B− — Shoppers who want a low flat price at every dose on compounded semaglutide or tirzepatide, with the option to save more on a three-month pack.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Yucca Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Yucca Health | Brightmeds |
|---|---|---|
| Cost-Efficiency Index | 83/100 | 82/100 |
| Semaglutide / mo | $146/moMonth to month, same price at every dose, compounded | $129/moCompounded, month to month, same price at every dose; $99/mo on a 3-month pack billed $297 |
| Tirzepatide / mo | $258/moMonth to month, same price at every dose, compounded | $149/moCompounded, month to month, same price at every dose; $119/mo on a 3-month pack billed $357 |
| Semaglutide / yr (modeled) | $1,752 | $1,548 |
| Tirzepatide / yr (modeled) | $3,096 | $1,788 |
| Coverage | All 50 states | 38 states + DC |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #23 | #28 |
Yucca Health
83/100Where the value is
- Each product page shows all three plans: semaglutide is $146 month to month, $140 a month on three months ($420) and $125 on six ($750); tirzepatide is $258, $248 ($744) and $225 ($1,350)
- The price is locked at every dose for as long as your plan stays active, and pausing keeps the lock
- A written six-month promise refunds everything you paid, including medication, if you follow the plan for six months and haven't lost weight from your logged starting weight
The tradeoffs
- The "$125/mo for life" banner is the six-month plan, billed $750 up front; the no-commitment monthly price is $146
- Once a clinician issues your prescription that order is final and can't be refunded, and you must cancel at least 7 days before a renewal to stop it
Brightmeds
82/100Where the value is
- Month-to-month prices of $129 for semaglutide and $149 for tirzepatide are on the pricing page, and the price stays the same as your dose goes up
- A three-month pack lowers that to $99 and $119 a month, and you can choose month to month instead
- Medication, clinician visits, dose adjustments and shipping are included, with no membership, consultation or lab fee
The tradeoffs
- The advertised GLP-1 prices apply only in 38 states and D.C.; if you are already on a GLP-1 or transferring a prescription, you must contact support for pricing
- Its terms say fees are otherwise non-refundable, and month-to-month plans renew automatically until you cancel
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.