Head-to-head · Cost-Efficiency Index
Youth & Soul vs AquaVita NextGen
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Youth & Soul
Shoppers who want a named compounding pharmacy and nationwide shipping with both compounded and branded GLP-1 options in one place.
Visit Youth & SoulAquaVita NextGen
Shoppers in AZ, CA, FL, TX, or NV who want a medspa-backed provider with a real street address.
Visit AquaVita NextGenThe verdict
Youth & Soul takes it, leading the Cost-Efficiency Index 61 to 60. Youth & Soul (live at youthnsoul.com, redirected from youthandsoul.com) is a GLP-1 telehealth platform offering compounded semaglutide and tirzepatide alongside branded Wegovy/Ozempic. AquaVita NextGen still earns a C — Shoppers in AZ, CA, FL, TX, or NV who want a medspa-backed provider with a real street address.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Youth & Soul.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Youth & Soul | AquaVita NextGen |
|---|---|---|
| Cost-Efficiency Index | 61/100 | 60/100 |
| Semaglutide / mo | $149/mo (compounded) | $215/mo (compounded) |
| Tirzepatide / mo | $149/mo (compounded) | $320/mo (compounded) |
| Semaglutide / yr (modeled) | $1,788 | $2,580 |
| Tirzepatide / yr (modeled) | $1,788 | $3,840 |
| Coverage | Coverage not published | 5 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Yes | Compounded only |
| Rank here | #239 | #244 |
Youth & Soul
61/100Where the value is
- Named, verifiable compounding pharmacy partner (Procompounding Pharmacy) plus a named fulfillment partner (The Pharmacy Hub)
- Claims all-50-state shipping
- LegitScript seal displayed
The tradeoffs
- Primary marketing domain (youthandsoul.com) simply redirects to a differently-spelled live site, which could confuse shoppers
- 'From $149/mo' headline price isn't broken out by exact dose, and the referenced 'Level 1-3' tier structure isn't fully published
AquaVita NextGen
60/100Where the value is
- Real, verifiable physical address (23321 El Toro Rd Suite G, Lake Forest, CA) rather than a web-only storefront
- Both semaglutide and tirzepatide offered, with a 3-month discount option on each ($600 and $900 respectively, cheaper per month than paying monthly)
- Explicit, plainly-worded compounding disclaimer present on the site
The tradeoffs
- Only 5 states served: Arizona, California, Florida, Texas, and Nevada — most of the country cannot use this provider
- No dose (mg/week) is disclosed for either the one-month or three-month listings, so it's unclear what strength $215 or $320 actually buys
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.