Head-to-head · Cost-Efficiency Index
YourEra vs AlyveRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
YourEra
Shoppers chasing the lowest sticker price who will verify what's actually billed after the first month.
Visit YourEraAlyveRx
Shoppers who specifically want a needle-free sublingual GLP-1 option alongside standard injections on the same platform.
Visit AlyveRxThe verdict
AlyveRx takes it, leading the Cost-Efficiency Index 64 to 62. AlyveRx (Alyve) is a telehealth platform selling compounded semaglutide and tirzepatide in both standard injection and proprietary PermeAct sublingual-drop form, plus brand Ozempic, Wegovy. YourEra still earns a C — Shoppers chasing the lowest sticker price who will verify what's actually billed after the first month.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs AlyveRx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | YourEra | AlyveRx |
|---|---|---|
| Cost-Efficiency Index | 62/100 | 64/100 |
| Semaglutide / mo | $179/mo (all doses, month-to-month, compounded) | $183/mo (starting dose, compounded) |
| Tirzepatide / mo | $259/mo (all doses, month-to-month, compounded) | $283/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $2,148 | $2,196 |
| Tirzepatide / yr (modeled) | $3,108 | $3,396 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #171 | #173 |
YourEra
62/100Where the value is
- A 6-month prepay drops semaglutide to $99/month, among the lowest compounded-GLP-1 headline prices we track
- No membership-fee structure; the site markets "no hidden fees" and "Same price at every dose"
- Prescriptions are "issued only if deemed medically appropriate" after evaluation by licensed US clinicians, stated plainly
The tradeoffs
- The advertised $99/month requires a 6-month prepay — paying month to month costs $149 for the first month and $179/month after, nearly double the headline
- Tirzepatide's advertised $179 is a first-month intro, not a prepay rung: the page's own words are "Month-to-month intro. Then $259/mo." — so the two molecules' headline discounts work in two different ways on one page
AlyveRx
64/100Where the value is
- Offers a genuinely needle-free sublingual delivery option (PermeAct) for both semaglutide and tirzepatide, not just injections
- Also carries brand-name Ozempic, Wegovy, and Mounjaro for patients who want an FDA-approved product
- All four price points (injection and drops, both drugs) are published upfront on the homepage before intake
The tradeoffs
- The dataset's previous $249/mo tirzepatide figure is the SUBLINGUAL DROPS price, not the standard injection ($283/mo) — confirm which form a quoted price refers to
- Sublingual PermeAct absorption relies on the company's own proprietary technology claims and is not FDA-reviewed for weight-loss efficacy
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.