Head-to-head · Cost-Efficiency Index
Sipra vs TrimRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Sipra
Shoppers ready to commit to at least three months who want a price that doesn't rise with the dose and a full price table before they start.
Visit SipraTrimRx
Shoppers who want one monthly package that covers the visit, the medication and shipping, and who will confirm the renewal price at checkout.
Visit TrimRxThe verdict
Sipra takes it, leading the Cost-Efficiency Index 78 to 77. Sipra's shortest GLP-1 plan is three months paid up front: $189 a month for compounded semaglutide and $249 for tirzepatide, the same at every dose, with nothing charged until a physician approves. TrimRx still earns a C — Shoppers who want one monthly package that covers the visit, the medication and shipping, and who will confirm the renewal price at checkout.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Sipra.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Sipra | TrimRx |
|---|---|---|
| Cost-Efficiency Index | 78/100 | 77/100 |
| Semaglutide / mo | $189/mo3-month plan, $567 charged up front, same price at every dose, compounded | $299/moMonth-to-month refill price; first month $199, compounded |
| Tirzepatide / mo | $249/mo3-month plan, $747 charged up front, same price at every dose, compounded | $399/moMonth-to-month refill price; first month $349, compounded |
| Semaglutide / yr (modeled) | $2,268 | $3,588 |
| Tirzepatide / yr (modeled) | $2,988 | $4,788 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #52 | #56 |
Sipra
78/100Where the value is
- A full price table by drug and plan length is published, and the price stays the same as your dose goes up
- Your card isn't charged until a licensed physician reviews and approves your treatment
- Injections, lower-dose microdose injections and dissolving tablets are all offered for both drugs
The tradeoffs
- There's no month-to-month option for GLP-1s: the shortest plan is three months, charged in one payment ($567 for semaglutide, $747 for tirzepatide)
- To stop the next order you have to cancel at least 13 days before your paid period ends
TrimRx
77/100Where the value is
- Each monthly package includes the telehealth consultation, the prescription, the medication and shipping, with no separate membership fee listed
- The homepage promises the price stays the same as your dose goes up, and offers to keep your current dose if you switch from another program
- Serves all 50 states, and the terms say so plainly
The tradeoffs
- The homepage says "Starting at $179" and "$259", but the terms list $199 and $349 for the first month and $299 and $399 for each follow-up month, so confirm which price applies to you before paying
- Once your prescription is sent to the pharmacy that month's order can't be refunded; refunds on prepaid multi-month plans must be requested within 28 days of payment
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.