Head-to-head · Cost-Efficiency Index
ShedRx (Shed) vs RxPepsDirect
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
ShedRx (Shed)
People who want a needle-free route or a brand-name option, and who will commit to twelve months to reach the lowest price.
Visit ShedRx (Shed)RxPepsDirect
Cost-first shoppers who want the all-in per-order cost of a compounded GLP-1 with no subscription, in 28 states.
Visit RxPepsDirectThe verdict
ShedRx (Shed) takes it, leading the Cost-Efficiency Index 87 to 60. The widest set of formats on the board — injection, drops, lozenges and a daily oral pill, plus a real brand Zepbound route — though its cheapest advertised rates need a year-long commitment. RxPepsDirect still earns a C — Cost-first shoppers who want the all-in per-order cost of a compounded GLP-1 with no subscription, in 28 states.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the board). See how it stacks up: CoreAge Rx vs ShedRx (Shed).
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | ShedRx (Shed) | RxPepsDirect |
|---|---|---|
| Cost-Efficiency Index | 87/100 | 60/100 |
| Semaglutide / mo | $199/mo ($159 on a 12-month plan) | $79/mo (starting dose, visit fee and shipping included, compounded) |
| Tirzepatide / mo | $299/mo ($239 on a 12-month plan) | $99/mo (starting dose, visit fee and shipping included, compounded) |
| Semaglutide / yr (modeled) | $2,388 | $948 |
| Tirzepatide / yr (modeled) | $3,588 | $1,188 |
| Coverage | All 50 states | 28 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank on the board | #3 | #239 |
ShedRx (Shed)
87/100Where the value is
- Four routes to a GLP-1 — injection, liquid drops, lozenges and a daily oral pill
- Brand Zepbound and Wegovy available alongside the compounded line
- Available in all 50 states, with health coaching included and a published 120-day weight-loss guarantee
The tradeoffs
- The advertised "as low as" prices ($159 semaglutide, $239 tirzepatide) require a TWELVE-MONTH commitment — month-to-month is $199 and $299
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
RxPepsDirect
60/100Where the value is
- Every component of the price is published on the site — the vial tiers, the flat visit charge and the flat overnight delivery — so the all-in monthly cost can be worked out before ordering
- No subscription and no commitment: you pay per order, and one visit charge covers up to three peptides on the same prescription
- Real 503A telehealth Rx — licensed NP/PA prescribers under medical director Dr. Jonathan Snipes (NPI 1821250077), dispensed by Optimal Balance Pharmacy, Texas Board #34829
The tradeoffs
- The advertised vial price is not the monthly cost: a flat $39 medical visit charge and $15 flat FedEx shipping land on every order, and the visit charge recurs on every reorder rather than once
- Higher doses need more than one vial a month and the site publishes no price for the dose you titrate up to, so the figure above is a floor
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.