Head-to-head · Cost-Efficiency Index
ShedRx (Shed) vs Layla
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
ShedRx (Shed)
People who want a needle-free route or a brand-name option, and who will commit to twelve months to reach the lowest price.
Visit ShedRx (Shed)Layla
People wanting oral or injectable semaglutide with a brand-inclusive glp-1 upgrade path.
Visit LaylaThe verdict
ShedRx (Shed) takes it, leading the Cost-Efficiency Index 87 to 70. The widest set of formats on the board — injection, drops, lozenges and a daily oral pill, plus a real brand Zepbound route — though its cheapest advertised rates need a year-long commitment. Layla still earns a C — People wanting oral or injectable semaglutide with a brand-inclusive glp-1 upgrade path.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the board). See how it stacks up: CoreAge Rx vs ShedRx (Shed).
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | ShedRx (Shed) | Layla |
|---|---|---|
| Cost-Efficiency Index | 87/100 | 70/100 |
| Semaglutide / mo | $199/mo ($159 on a 12-month plan) | $237/mo (all doses, compounded) |
| Tirzepatide / mo | $299/mo ($239 on a 12-month plan) | $199/mo (all doses, compounded) |
| Semaglutide / yr (modeled) | $2,388 | $2,844 |
| Tirzepatide / yr (modeled) | $3,588 | $2,388 |
| Coverage | All 50 states | Coverage not published |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Yes | Yes |
| Rank on the board | #3 | #102 |
ShedRx (Shed)
87/100Where the value is
- Four routes to a GLP-1 — injection, liquid drops, lozenges and a daily oral pill
- Brand Zepbound and Wegovy available alongside the compounded line
- Available in all 50 states, with health coaching included and a published 120-day weight-loss guarantee
The tradeoffs
- The advertised "as low as" prices ($159 semaglutide, $239 tirzepatide) require a TWELVE-MONTH commitment — month-to-month is $199 and $299
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
Layla
70/100Where the value is
- Oral semaglutide dropper option plus injectable semaglutide and tirzepatide, with a brand-name upgrade path
- Named Medical Director (Dr. Ruth Cohen) and 24-7 doctor messaging
- Quiz-based intake with fast three to five day shipping
The tradeoffs
- Brand-inclusive GLP-1 program is expensive, starting around 1,299 dollars
- States served are not published on the site
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.