Head-to-head · Cost-Efficiency Index
Rex MD vs Premium Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rex MD
Cost-first shoppers who want men wanting brand-name Wegovy/Zepbound access through a manufacturer direct-pay bridge, not compounded medication.
Visit Rex MDPremium Health
Cost-first shoppers who want an all-inclusive compounded GLP-1 membership with three named pharmacy partners, if you won't need the higher dose tiers.
Visit Premium HealthThe verdict
Rex MD takes it, leading the Cost-Efficiency Index 56 to 55. Rex MD (a LifeMD brand, historically known for ED telehealth) also runs a real weight-management program, but it is a referral model rather than a compounder: a $75/month Rex MD program fee covers consultation, coaching and labs. Premium Health still earns a C — Cost-first shoppers who want an all-inclusive compounded GLP-1 membership with three named pharmacy partners, if you won't need the higher dose tiers.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Rex MD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rex MD | Premium Health |
|---|---|---|
| Cost-Efficiency Index | 56/100 | 55/100 |
| Semaglutide / mo | $574/mo (all doses, plus a separate fee, brand-name) | $275/mo (compounded) |
| Tirzepatide / mo | $424/mo (brand Zepbound, plus a separate fee) | $445/mo (compounded) |
| Semaglutide / yr (modeled) | $6,888 | $3,300 |
| Tirzepatide / yr (modeled) | $5,088 | $5,340 |
| Coverage | All 50 states | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #331 | #335 |
Rex MD
56/100Where the value is
- Genuine FDA-approved brand-name medication (Wegovy, Zepbound, Saxenda) rather than compounded — a different, more regulated tier than most of this list
- Named medical leadership (Dr. Anthony Puopolo, M.D., Rex MD Affiliated Medical Group) and a LegitScript Certified badge
- Backed by publicly known parent LifeMD, with an established telehealth track record
The tradeoffs
- The headline $75 is NOT the medication cost — Wegovy runs an additional $499/mo (any dose) and Zepbound vials an additional $349/mo, both billed separately by the manufacturer, not Rex MD
- All-in realistic cost is roughly $424-$574/month, far above what a '$75' or even a '$349' headline implies depending on which landing page you see
Premium Health
55/100Where the value is
- All-inclusive flat pricing stated to cover medical consultation, provider visits, medication, supplies, and shipment in one number
- Month-to-month with 'the option to cancel anytime if unsatisfied' — no long-term contract
- Names three real, licensed pharmacy partners (Hallandale Pharmacy, Red Rock Pharmacy, Strive Pharmacy)
The tradeoffs
- The $275/$445 base price is NOT the ceiling: reaching the higher labeled doses costs an additional $100/mo or $150/mo, pushing the real cost to $375-$595/mo
- Compounded medications are not FDA-approved
Regulatory note: the FDA issued a warning letter to Premium Health Management Inc. dba Premium Health in February 2026. We still list and link to Premium Health; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.