Head-to-head · Cost-Efficiency Index
PCOS Sisters vs Empower Pharmacy
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
PCOS Sisters
Cost-first shoppers who want women with PCOS who want GLP-1 prescribing folded into a specialty metabolic-care membership.
Visit PCOS SistersEmpower Pharmacy
Cost-first shoppers who want not a fit for this review format -- it is a wholesale/fulfillment pharmacy, not a direct-to-consumer prescriber.
Visit Empower PharmacyThe verdict
PCOS Sisters takes it, leading the Cost-Efficiency Index 52 to 51. PCOS Sisters is a women's telehealth clinic (Albuquerque, NM-based) specializing in PCOS care, offering GLP-1 prescribing as one part of its Metabolic Weight Loss Program. Empower Pharmacy still earns a C — Cost-first shoppers who want not a fit for this review format -- it is a wholesale/fulfillment pharmacy, not a direct-to-consumer prescriber.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs PCOS Sisters.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | PCOS Sisters | Empower Pharmacy |
|---|---|---|
| Cost-Efficiency Index | 52/100 | 51/100 |
| Semaglutide / mo | Not disclosed | Not disclosed |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | — | — |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | 12 states | All 50 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #390 | #394 |
PCOS Sisters
52/100Where the value is
- Dedicated PCOS specialty model with a metabolic weight-loss program and fitness app bundled into the membership
- Two named pharmacy partners with full addresses published (Strive Pharmacy, Gilbert AZ; Striker Pharmacy, Katy TX)
- LegitScript and BBB verification badges both present on-site
The tradeoffs
- The advertised $150/month does NOT include the GLP-1 medication itself — the site's own FAQ confirms medication is billed separately by the pharmacy, so the real all-in cost is higher and undisclosed
- Only 11 states served (not 12), with no public timeline for expansion beyond 'working to expand our coverage'
Empower Pharmacy
51/100Where the value is
- Large, established 503A/503B compounding pharmacy with LegitScript-style certification displayed
- Serves as the fulfillment backend for many telehealth companies (indirect national reach)
The tradeoffs
- No direct-to-consumer prescribing path -- it does not evaluate or prescribe to new patients itself
- No public retail pricing anywhere on the site
Full Empower Pharmacy review →
Regulatory note: the FDA issued a warning letter to Empower Clinic Services, LLC dba Empower Pharmacy in April 2025. We still list and link to Empower Pharmacy; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.