Head-to-head · Cost-Efficiency Index
One80Rx vs Wellorithm
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
One80Rx
Shoppers who want an injectable or oral GLP-1 with peptide therapies on the same account and will confirm their exact price after the provider review.
Visit One80RxWellorithm
Shoppers who want brand-name Wegovy, Ozempic, Zepbound or Mounjaro at a cash price, with compounded options to discuss with a clinician.
Visit WellorithmThe verdict
One80Rx and Wellorithm tie on the Cost-Efficiency Index at 72/100, so neither wins outright on the numbers, so choose on fit. One80Rx: Shoppers who want an injectable or oral GLP-1 with peptide therapies on the same account and will confirm their exact price after the provider review. Wellorithm: Shoppers who want brand-name Wegovy, Ozempic, Zepbound or Mounjaro at a cash price, with compounded options to discuss with a clinician.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs One80Rx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | One80Rx | Wellorithm |
|---|---|---|
| Cost-Efficiency Index | 72/100 | 72/100 |
| Semaglutide / mo | $129/moStarting price, compounded; confirmed after provider review | $899/moBrand Wegovy; fine print ties the price to a 3-month plan paid upfront |
| Tirzepatide / mo | $229/moStarting price, compounded; confirmed after provider review | $1,199/moBrand Zepbound; fine print ties the price to a 3-month plan paid upfront |
| Semaglutide / yr (modeled) | $1,548 | $10,788 |
| Tirzepatide / yr (modeled) | $2,748 | $14,388 |
| Coverage | Not published | All 50 states and D.C. |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #103 | #104 |
One80Rx
72/100Where the value is
- Starting prices for every program are listed on its treatments page: semaglutide $129, a GLP-1 microdose $149, an oral GLP-1 $149 and tirzepatide $229 a month
- Promises flat-rate pricing with no consultation charge and no surcharge when your dose changes
- You pay $0 if you aren't approved, and shipping is free in two to three days
The tradeoffs
- Every price is a "from" figure, and the site says plans are confirmed after provider review, so the price for your dose isn't published
- The semaglutide and tirzepatide program pages show no price at all; the figures appear only on the homepage banner and the treatments list
Wellorithm
72/100Where the value is
- Brand-name prices are on the product pages before any quiz: Wegovy $899, Ozempic and Zepbound $1,199, Mounjaro $1,399 a month
- Sells brand-name pens, compounded semaglutide injections and oral dissolving GLP-1 tablets under one account
- Names three of its partner physicians on the product pages
The tradeoffs
- Compounded semaglutide and the oral tablets have no published price; you see it only after the quiz
- The fine print under each brand price says it applies to a 3-month plan paid upfront, while the same page says 'per month', so confirm the billing before you pay
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.