Head-to-head · Cost-Efficiency Index
Nolu vs Cielo
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Nolu
Shoppers who want GLP-1 plus an adjacent microdose or NAD+/longevity line without juggling separate accounts.
Visit NoluCielo
Shoppers comfortable committing to an undisclosed-structure 6-month plan for a flat, dose-independent price.
Visit CieloThe verdict
Nolu and Cielo tie on the Cost-Efficiency Index at 68/100, so neither wins outright on the numbers. For most shoppers we'd start with Nolu (ranked #111, a hair above #115) — Shoppers who want GLP-1 plus an adjacent microdose or NAD+/longevity line without juggling separate accounts. But Cielo is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Nolu.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Nolu | Cielo |
|---|---|---|
| Cost-Efficiency Index | 68/100 | 68/100 |
| Semaglutide / mo | $249 (billed per 4 weeks, ~8% above nominal monthly) | $89/mo (all doses, 6-month plan, compounded) |
| Tirzepatide / mo | $339 (billed per 4 weeks, ~8% above nominal monthly) | $129/mo (all doses, 6-month plan, compounded) |
| Semaglutide / yr (modeled) | $2,988 | $1,068 |
| Tirzepatide / yr (modeled) | $4,068 | $1,548 |
| Coverage | All 50 states + Washington, D.C. (standard eligibility hedge) | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #111 | #115 |
Nolu
68/100Where the value is
- Both molecules published up front — $249 semaglutide, $339 tirzepatide — plus an oral semaglutide tablet option
- All-inclusive per-cycle pricing: consultation, medication and shipping bundled, no separate membership fee
- LegitScript verified
The tradeoffs
- Billed every 4 weeks, not per calendar month — 13 charges a year, not 12, so the real annualized cost runs ~8% above the headline figure
- No named medical director, prescriber, or compounding pharmacy disclosed anywhere on the site
Cielo
68/100Where the value is
- Flat pricing regardless of dose for both semaglutide and tirzepatide, avoiding per-mg price escalation during titration
- Free physician consult and free shipping stated as included
- Claims 'Every batch tested', at least asserting quality-control testing exists
The tradeoffs
- The '6-month plan' mechanics are never explained — whether it's a one-time prepayment or a 6-month billing lock is unknown, which is exactly the kind of commitment term that should be disclosed before signup
- No pharmacy, medical director, or prescriber is named anywhere on the accessible site
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.