Head-to-head · Cost-Efficiency Index
MadeMed vs Vyvron
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
MadeMed
Shoppers comfortable paying three months at a time who want one flat price at every dose, or a no-needle sublingual semaglutide tablet.
Visit MadeMedVyvron
Shoppers who want one all-in price with no membership fee and are comfortable budgeting for a four-week billing cycle.
Visit VyvronThe verdict
MadeMed and Vyvron tie on the Cost-Efficiency Index at 68/100, so neither wins outright on the numbers, so choose on fit. MadeMed: Shoppers comfortable paying three months at a time who want one flat price at every dose, or a no-needle sublingual semaglutide tablet. Vyvron: Shoppers who want one all-in price with no membership fee and are comfortable budgeting for a four-week billing cycle.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs MadeMed.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | MadeMed | Vyvron |
|---|---|---|
| Cost-Efficiency Index | 68/100 | 68/100 |
| Semaglutide / mo | $239/moQuarterly plan, billed $717 every 3 months, same price at every dose, compounded | $199Every 4 weeks (founding-member price; $249 after the founding spots fill, compounded) |
| Tirzepatide / mo | $399/moQuarterly plan, billed $1,197 every 3 months, same price at every dose, compounded | Not disclosed |
| Semaglutide / yr (modeled) | $2,868 | $2,58713 charges |
| Tirzepatide / yr (modeled) | $4,788 | — |
| Coverage | 23 states | 49 states (not Mississippi) |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #161 | #162 |
MadeMed
68/100Where the value is
- One flat price at every dose, printed dose by dose on each product page
- Offers sublingual semaglutide tablets ($219 a month quarterly) and oral tirzepatide alongside the injections
- You can cancel or pause in one click from your dashboard, and it emails you 7 days before every charge
The tradeoffs
- There is no monthly plan; the shortest commitment is three months, billed up front
- Injectable semaglutide is offered in only 23 states, fewer than the 40 the service lists overall, so check your state on the product page
Vyvron
68/100Where the value is
- One price covers the provider evaluation, the medication if prescribed, ongoing check-ins and shipping, with no membership fee
- No long-term contract and no cancellation fee; you cancel by email or in the patient portal
- Full refund if a provider doesn't approve you
The tradeoffs
- Billing is every four weeks, not monthly, so a year at $199 is 13 charges and $2,587
- The pages don't say whether tirzepatide costs the same as semaglutide; the provider chooses which one you get
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.