Head-to-head · Cost-Efficiency Index
Lttl vs SmartPharmaRX
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Lttl
Shoppers who want a low price without prepaying, and who are fine with a refill that ships and bills every four weeks.
Visit LttlSmartPharmaRX
Patients whose provider already e-prescribes to SmartPharmaRX; it isn't a place to start GLP-1 treatment.
Visit SmartPharmaRXThe verdict
Lttl takes it, leading the Cost-Efficiency Index 61 to 36. Lttl charges $99 every four weeks for compounded semaglutide and $149 for tirzepatide on a cancel-anytime auto-refill, with small discounts for longer supplies. SmartPharmaRX still earns a C — Patients whose provider already e-prescribes to SmartPharmaRX; it isn't a place to start GLP-1 treatment.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Lttl.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Lttl | SmartPharmaRX |
|---|---|---|
| Cost-Efficiency Index | 61/100 | 36/100 |
| Semaglutide / mo | $99 per 4 weeksCompounded, auto-refill | Not disclosed |
| Tirzepatide / mo | $149 per 4 weeksCompounded, auto-refill | Not disclosed |
| Semaglutide / yr (modeled) | $1,28713 charges | — |
| Tirzepatide / yr (modeled) | $1,93713 charges | — |
| Coverage | Coverage not published | Not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #230 | #620 |
Lttl
61/100Where the value is
- Every medication and supply length is priced on its plans page before checkout
- Longer supplies trim the price only a little: semaglutide is $96, $93 or $89 per four weeks on 12-, 24- or 52-week supplies, so month to month costs you almost nothing extra
- Named medical advisory board (pharmacist, nurse practitioner, physical therapist) rather than zero disclosure
The tradeoffs
- Billing is every four weeks, so a year is 13 charges: about $1,287 on semaglutide and $1,937 on tirzepatide
- The struck-through $249 and $339 beside each price are not a price anyone is quoted, so ignore the "savings" figures
SmartPharmaRX
36/100Where the value is
- A 503A compounding pharmacy that lists tirzepatide and semaglutide under GLP-1 therapies
- Says each preparation is tested for sterility and potency, with endotoxin screening
- Its FAQ says plainly that compounded medications are not FDA-approved
The tradeoffs
- Prescriptions have to come from your provider's e-prescribing system; there's no patient sign-up
- Says it is licensed in 'select states' without listing them
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.