Head-to-head · Cost-Efficiency Index
Lean Meds vs Yucca Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Lean Meds
Cost-first shoppers who want a genuinely flat all-dose price and named pharmacies, and who will read the $49 headline as the annual plan it is.
Visit Lean MedsYucca Health
Shoppers who want a flat monthly price that won't rise as the dose goes up, with the option to pause instead of cancel.
Visit Yucca HealthThe verdict
Lean Meds takes it, leading the Cost-Efficiency Index 84 to 83. Lean Meds charges $79 a month for compounded semaglutide and $109 for tirzepatide, flat at every dose, names the four pharmacies that fill the prescriptions, and advertises a $49 figure that is really its twelve-month rate. Yucca Health still earns a B — Shoppers who want a flat monthly price that won't rise as the dose goes up, with the option to pause instead of cancel.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Lean Meds.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Lean Meds | Yucca Health |
|---|---|---|
| Cost-Efficiency Index | 84/100 | 83/100 |
| Semaglutide / mo | $79/moMonth-to-month, flat at every dose (the advertised $49 is the 12-month plan) | $146/moMonth to month, same price at every dose, compounded |
| Tirzepatide / mo | $109/moMonth-to-month, flat at every dose (the advertised $95 is the 12-month plan) | $258/moMonth to month, same price at every dose, compounded |
| Semaglutide / yr (modeled) | $948 | $1,752 |
| Tirzepatide / yr (modeled) | $1,308 | $3,096 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #21 | #23 |
Lean Meds
84/100Where the value is
- A flat rate at every dose on both molecules, stated as such, so the price does not climb as a provider titrates
- Names all four pharmacies in its network with addresses, phone numbers and websites, and states the 503A designation in the footer of every page
- The full four-rung ladder for each molecule is printed on one page, so a reader can see what a commitment actually saves
The tradeoffs
- The homepage sells "Starting at $49/mo — same price every month, first order and every order after"; $49 is the twelve-month semaglutide plan and the month-to-month rate is $79
- A homepage chip reads "No auto rebill" while the terms say the payment method is automatically charged at recurring intervals until you cancel
Yucca Health
83/100Where the value is
- Each product page shows all three plans: semaglutide is $146 month to month, $140 a month on three months ($420) and $125 on six ($750); tirzepatide is $258, $248 ($744) and $225 ($1,350)
- The price is locked at every dose for as long as your plan stays active, and pausing keeps the lock
- A written six-month promise refunds everything you paid, including medication, if you follow the plan for six months and haven't lost weight from your logged starting weight
The tradeoffs
- The "$125/mo for life" banner is the six-month plan, billed $750 up front; the no-commitment monthly price is $146
- Once a clinician issues your prescription that order is final and can't be refunded, and you must cancel at least 7 days before a renewal to stop it
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.