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Head-to-head · Cost-Efficiency Index

iThriveMD vs Semaglutide Online

Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.

Better valueGrade C · #194

iThriveMD

People in the CA/AZ service area who want the option of in-person visits alongside telehealth.

Visit iThriveMD
VS
Grade C · #200

Semaglutide Online

Shoppers who want one all-inclusive compounded price with no add-on provider fee, and don't mind the site's own numbers not always agreeing.

Visit Semaglutide Online

The verdict

Too close to callGrade C vs C

iThriveMD and Semaglutide Online tie on the Cost-Efficiency Index at 63/100, so neither wins outright on the numbers. For most shoppers we'd start with iThriveMD (ranked #194, a hair above #200) — People in the CA/AZ service area who want the option of in-person visits alongside telehealth. But Semaglutide Online is a genuine coin-flip alternative here.

Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs iThriveMD.

Factor by factor

Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.

Normalized Cost/Month

57
45

Price Transparency

94
54

Nationwide Access

24
86

Formulation Options

66
64

Clinical Oversight

90
81

Contract Flexibility

47
55

Pricing, coverage & formulary

The disclosed facts behind the scores. Lower price wins its row (teal).

SpeciThriveMDSemaglutide Online
Cost-Efficiency Index63/10063/100
Semaglutide / mo$199/mo (all doses, promotional rate, compounded)Not disclosed
Tirzepatide / mo$399/mo (microdose tier, starting dose, compounded)Not disclosed
Semaglutide / yr (modeled)$2,388
Tirzepatide / yr (modeled)$4,788
CoverageCoverage not publishedAll 50 states
Oral / sublingualNoYes
Brand-name accessCompounded onlyYes
Rank here#194#200

iThriveMD

63/100

Where the value is

  • LegitScript-certified pharmacy claim, not just a generic compliance statement
  • Real physical locations for patients who want in-person care
  • Flat 'same price at all doses' structure for semaglutide simplifies comparison shopping

The tradeoffs

  • $199 headline price is explicitly a teaser that reverts to $299/mo
  • No individually named medical director
Visit iThriveMD

Full iThriveMD review →

Semaglutide Online

63/100

Where the value is

  • Compounded tier is genuinely all-inclusive — no separate $44/mo provider subscription, unlike its own branded-drug track
  • Offers 0% interest financing plans (12 or 24 months) for those who want to spread the cost
  • No long-term contract — site states you can cancel anytime

The tradeoffs

  • The compounded semaglutide price is internally inconsistent on the site's own product page — $179/mo appears in one place, $199/mo (all-inclusive) in another, with no reconciliation
  • Brand-name options carry a headline medication price that excludes a mandatory separate $44/mo provider subscription, understating the real all-in cost by nearly 20%
Visit Semaglutide Online

Full Semaglutide Online review →

Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.

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