Head-to-head · Cost-Efficiency Index
Invyncible vs Telos Rx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Invyncible
Cost-first shoppers who want compounded GLP-1 combo programs (with B12/glycine) alongside brand Wegovy/Zepbound on one platform.
Visit InvyncibleTelos Rx
Needle-averse shoppers pricing an oral tirzepatide tablet at a flat rate that does not climb with the dose, and who accept that the injectable side of the menu will not quote a standing price until they are inside the funnel.
Visit Telos RxThe verdict
Invyncible takes it, leading the Cost-Efficiency Index 59 to 56. Invyncible (operated by Nationwide Telemedicine, LLC, St. Petersburg, FL) sells four semaglutide combo programs ($149-$270) and four tirzepatide combo programs ($180-$318.75), plus an oral semaglutide capsule program at $255.50, across 46 states and DC. Telos Rx still earns a C — Needle-averse shoppers pricing an oral tirzepatide tablet at a flat rate that does not climb with the dose, and who accept that the injectable side of the menu will not quote a standing price until they are inside the funnel.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Invyncible.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Invyncible | Telos Rx |
|---|---|---|
| Cost-Efficiency Index | 59/100 | 56/100 |
| Semaglutide / mo | $149/mo (0.45 mg dose, compounded with glycine + B12) | Not disclosed — intake-gated |
| Tirzepatide / mo | $180/mo (2.5 mg weekly, 4-week program, compounded) | $229/mo oral tablets (a Telos month is 4 weeks; injectable not published) |
| Semaglutide / yr (modeled) | $1,788 | — |
| Tirzepatide / yr (modeled) | $2,160 | $2,748 |
| Coverage | 46 states plus DC | Claims 50 states; per-service limits unpublished |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Yes | Compounded only |
| Rank here | #272 | #278 |
Invyncible
59/100Where the value is
- Publishes real itemized dollar prices for eight separate combo programs plus two brand options directly on the site, no signup required, with the mg vial size named in every dose option
- Sells FDA-approved brand Wegovy ($1,750/mo) and Zepbound ($1,540/mo) alongside compounded options
- Names all six compounding pharmacies with street addresses and phone numbers and lets the patient choose which one fills the prescription
The tradeoffs
- Every listed price is shown as a discount off a much higher struck-through 'list' price, and the page invites further negotiation — reads as permanent anchor pricing
- The entry figure is the smallest vial: plain compounded semaglutide runs $192.50, $262.50 and $350 across its three vial sizes, and the FAQ confirms cost rises with dose
Telos Rx
56/100Where the value is
- One ladder is published properly, and it is published the honest way: oral tirzepatide at $199/$129/$99/$49 for the first month with the standing $229/$159/$139/$129 printed beside it, so the step-up is visible before you buy
- Fees are itemised as waived rather than merely absent — visit fee $49→$0, shipping $25→$0, dose adjustments $0, 24/7 support $0, membership $0, and "Pay $0 if not approved"
- Flat pricing that does not rise as the dose is titrated, which is the single most common way a cheap first month becomes an expensive fourth one
The tradeoffs
- The injectable rung tables are not public at all — those cards read "Start your intake for pricing", so the $99 semaglutide and $139 tirzepatide on the marketing pages are first-month floors on the deepest prepay plan with no standing rate published anywhere
- Its own pages disagree: /pages/oral-tirzepatide advertises "as low as $129/month" while the gender landers price the same 12-month plan at $49 first month and $129 after, so the headline is the post-intro rate of a plan the headline does not mention
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.