Head-to-head · Cost-Efficiency Index
Enhance MD vs PreventiveMD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Enhance MD
Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Visit Enhance MDPreventiveMD
Cost-first shoppers who want compounded GLP-1s from $83/mo all-in, with brand upgrade paths.
Visit PreventiveMDThe verdict
PreventiveMD takes it, leading the Cost-Efficiency Index 77 to 75. PreventiveMD is a physician-guided telehealth platform for GLP-1 weight loss and peptide therapy, offering compounded semaglutide from $83/mo all-in and compounded tirzepatide from $97/mo all-in. Enhance MD still earns a C — Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs PreventiveMD.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Enhance MD | PreventiveMD |
|---|---|---|
| Cost-Efficiency Index | 75/100 | 77/100 |
| Semaglutide / mo | $212/mo (first month $112) | $83/mo (as low as, term not published, all-in, compounded) |
| Tirzepatide / mo | $280/mo (first month $180) | $97/mo (as low as, term not published, all-in, compounded) |
| Semaglutide / yr (modeled) | $2,544 | $996 |
| Tirzepatide / yr (modeled) | $3,360 | $1,164 |
| Coverage | Not disclosed | 36 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #43 | #44 |
Enhance MD
75/100Where the value is
- Fully published, dose-flat tiered pricing — sema $212/mo, tirz $280/mo, microdose $169/mo, sema+tirz combo $322/mo — no quiz or quote wall
- The rate does not climb as your dose is titrated up, unlike per-mg pricing elsewhere in this ranking
- Routine lab work at the 6-month mark plus ongoing provider messaging is bundled into the price, not sold separately
The tradeoffs
- Compounded only — no FDA-approved brand-name route (no Wegovy, Ozempic, Mounjaro or Zepbound)
- No oral or sublingual GLP-1 option (injection only)
PreventiveMD
77/100Where the value is
- Compounded semaglutide from $83/mo and tirzepatide from $97/mo, billed as one all-in monthly price
- Brand Wegovy, Zepbound, and Foundayo (oral GLP-1) available on the same platform
- US-licensed provider reviews requests within 24 hours — no video visit required
The tradeoffs
- Both figures are 'as low as' rates and the qualifying term is not published anywhere — the checkout is gated, so whether $97 is month-to-month or a multi-month prepay cannot be established before signing up
- Brand-name routes are priced separately and do carry a fee: $49/mo membership plus medication from $149/mo for Foundayo and Wegovy, from $299/mo for Zepbound
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.