Head-to-head · Cost-Efficiency Index
Edessa vs Zappy Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Edessa
A six-month committer, or someone willing to click past the front page to the table with the real monthly rate.
Visit EdessaZappy Health
Shoppers who want both compounded and brand GLP-1 options on one platform and are comfortable weighing a recent FDA misbranding finding.
Visit Zappy HealthThe verdict
Edessa takes it, leading the Cost-Efficiency Index 70 to 69. Clean three-rung tables one click in, behind a front page whose three cards all quote six-month rungs and whose cheapest belongs to a different drug. Zappy Health still earns a C — Shoppers who want both compounded and brand GLP-1 options on one platform and are comfortable weighing a recent FDA misbranding finding.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Edessa.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Edessa | Zappy Health |
|---|---|---|
| Cost-Efficiency Index | 70/100 | 69/100 |
| Semaglutide / mo | $179/mo month-to-month for the injection; $160 on three months and $135 on six | $159/mo (starting dose, compounded) |
| Tirzepatide / mo | $239/mo month-to-month; $219 on three months and $209 on six | $279/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $2,148 | $1,908 |
| Tirzepatide / yr (modeled) | $2,868 | $3,348 |
| Coverage | Not disclosed | 42 states |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Yes |
| Rank here | #91 | #93 |
Edessa
70/100Where the value is
- Each product page carries a plain three-rung table, so the commitment behind every figure is visible
- "Same price, every dose" is printed on each product page
- Names its operating entity and a full street address in Las Vegas, Nevada
The tradeoffs
- The front page leads with "Start for just $135", a six-month prepay on the semaglutide injection
- All three front-page cards quote the six-month rung, so the real monthly rates appear only after a click
Zappy Health
69/100Where the value is
- Both compounded semaglutide/tirzepatide and brand Wegovy/Zepbound pathways offered on one platform
- No insurance or membership required; cash-pay pricing displayed before intake
- LegitScript badge displayed on the site
The tradeoffs
- Does not name its dispensing pharmacy
- No named medical director or prescriber found
Regulatory note: the FDA issued a warning letter to Kare Solutions, LLC dba Zappy in February 2026. We still list and link to Zappy Health; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.