Head-to-head · Cost-Efficiency Index
Bionomy Health vs Edessa
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Bionomy Health
Cost-first shoppers who want men wanting physician-led GLP-1 plus TRT and longevity add-ons.
Visit Bionomy HealthEdessa
A six-month committer, or someone willing to click past the front page to the table with the real monthly rate.
Visit EdessaThe verdict
Bionomy Health and Edessa tie on the Cost-Efficiency Index at 70/100, so neither wins outright on the numbers. For most shoppers we'd start with Bionomy Health (ranked #86, a hair above #91) — Cost-first shoppers who want men wanting physician-led GLP-1 plus TRT and longevity add-ons. But Edessa is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Bionomy Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Bionomy Health | Edessa |
|---|---|---|
| Cost-Efficiency Index | 70/100 | 70/100 |
| Semaglutide / mo | $189/mo (starting dose, compounded) | $179/mo month-to-month for the injection; $160 on three months and $135 on six |
| Tirzepatide / mo | $249/mo (compounded) | $239/mo month-to-month; $219 on three months and $209 on six |
| Semaglutide / yr (modeled) | $2,268 | $2,148 |
| Tirzepatide / yr (modeled) | $2,988 | $2,868 |
| Coverage | 48 states | Not disclosed |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #86 | #91 |
Bionomy Health
70/100Where the value is
- Cancellation is genuinely unconditional: no subscription, no card on file, no auto-renewal, no cancellation fee — you pay per refill
- Prices are published before intake on a dedicated GLP-1 page, and the same figures appear in the site's own llms.txt
- Available in 48 states
The tradeoffs
- The $189 is a starting rate, not a flat one: the page says 'From', the product card says 'Starter', and doses are titrated every four weeks with no published price for the dose you end up on
- The homepage says muscle preservation is 'included' while the GLP-1 page sells a Muscle Preserve Pack at $109/mo as a separate line item
Edessa
70/100Where the value is
- Each product page carries a plain three-rung table, so the commitment behind every figure is visible
- "Same price, every dose" is printed on each product page
- Names its operating entity and a full street address in Las Vegas, Nevada
The tradeoffs
- The front page leads with "Start for just $135", a six-month prepay on the semaglutide injection
- All three front-page cards quote the six-month rung, so the real monthly rates appear only after a click
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.